ArticlePloS one2014
Assessment of predictive markers for placental inflammatory response in preterm births.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool.American journal of obstetrics and gynecology · 2015Trial
- First-Trimester Maternal CALLY Index Is Associated With Fetal Growth Restriction.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- The neutrophil-to-lymphocyte ratio: a marker for microbial invasion of the amniotic cavity in preterm prelabor rupture of membranes.Obstetrics & gynecology science · 2026Article
- Predictive Value of Neutrophils, Lymphocytes, Platelets, Neutrophil-Lymphocyte Ratio (NLR), and Platelets-Lymphocyte Ratio (PLR) in Preterm Labor: Single and Combined Indices.Obstetrics and gynecology international · 2026Article
- Interleukin 6 for the Prediction of Chorioamnionitis: A Systematic Review and Meta-Analysis.Biomedicines · 2025Review
- Interpretable machine learning model for identification and risk factor of premature rupture of membranes (PROM) and its association with nutritional inflammatory index: a retrospective study.Frontiers in medicine · 2025Article
- Cargo exchange between human and bacterial extracellular vesicles in gestational tissues: a new paradigm in communication and immune development.Extracellular vesicles and circulating nucleic acids · 2024Review
- Laboratory markers to identify acute histological chorioamnionitis in febrile parturients undergoing epidural analgesia: a retrospective study.BMC pregnancy and childbirth · 2023Article
- Article
- Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratio in Preterm Premature Rupture of Membranes.Cureus · 2023Article
- Article
- Predictive value of serum inflammatory markers for histological chorioamnionitis among women with preterm premature rupture of membranes after undergoing cervical cerclage.Clinics (Sao Paulo, Brazil) · 2023Article
- Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways.Frontiers in endocrinology · 2022Review
- Neutrophil-lymphocyte ratio for the prediction of histological chorioamnionitis in cases of preterm premature rupture of membranes: a case-control study.BMC pregnancy and childbirth · 2021Article
- Neutrophil to Lymphocyte Ratio in Maternal Blood: A Clue to Suspect Amnionitis.Journal of clinical medicine · 2021Article
- Elevated neutrophil-lymphocyte ratios in extremely preterm neonates with histologic chorioamnionitis.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes.Scientific reports · 2021Article
- [Effect of different antibiotic use strategies on infection in neonates with premature rupture of membranes and high-risk factors for neonatal infection].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Multimodality Screening for Lower Genital Tract Infections Between 18 and 24 Weeks of Pregnancy and its Efficacy in Predicting Spontaneous Preterm Delivery.Journal of obstetrics and gynaecology of India · 2020Article
- DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births.Epigenetics & chromatin · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placental inflammatory response (PIR) is associated with adverse neonatal outcomes such as sepsis, cerebral palsy, low birth weight, preterm birth, and neonatal mortality. However, there is an urgent need for noninvasive and sensitive biomarkers for prediction of PIR. In this study, we evaluated the clinical usefulness of maternal serum inflammatory markers for prediction of PIR in women with impending preterm birth. We conducted a retrospective cohort study of 483 patients who delivered preterm neonates. Serum levels of leukocyte differential counts, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were compared between women with no placental inflammation and women with PIR. The mean neutrophil counts, CRP levels, and NLR in both the patients with histologic chorioamnionitis (HCA) alone and those with HCA with funisitis were significantly higher than those in women with no placental inflammation. Compared to leukocyte subset or CRP, NLR in women with funisitis was significantly higher than in women with HCA alone and showed higher predictive accuracy, along with 71.4% sensitivity, 77.9% specificity, 80.7% positive predictive value, and 67.8% negative predictive value for prediction of PIR. On Kaplan-Meier survival analysis, women with both an elevated level of CRP and a high NLR had a shorter admission-to-delivery interval compared to women with either an elevated level of CRP or a high NLR alone. NLR may be a predictive marker of PIR and could be used as a cost-effective parameter for identifying women at risk of PIR.
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