Evidence map›Paper›PMID 25291150›Full record

ArticleBioconjugate chemistry2014

Bone-targeted acid-sensitive doxorubicin conjugate micelles as potential osteosarcoma therapeutics.

Stewart A Low, Jiyuan Yang, Jindřich Kopeček

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stewart A LowDepartment of Bioengineering and ‡Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah , Salt Lake City, Utah 84112, United States.
Jiyuan Yang
Jindřich Kopeček
University of Utah · US

Funding

BONE TARGETED DELIVERY OF ANABOLIC AGENTSR01GM069847 · NIGMS · UNIVERSITY OF UTAH · PI KOPECEK, JINDRICH H. · 2004 to 2011
$2.3M
Intramural NIH HHSNIGMS NIH HHS R01 GM069847NIGMS NIH HHS R01 GM69847
6 · The paper itself

Abstract

Osteosarcoma is a malignancy of the bone that primarily affects adolescents. Current treatments retain mortality rates, which are higher than average cancer mortality rates for the adolescent age group. We designed a micellar delivery system with the aim to increase drug accumulation in the tumor and potentially reduce side effects associated with chemotherapy. The design features are the use of the hydrophilic D-aspartic acid octapeptide as both the effective targeting agent as well as the hydrophilic micelle corona. Micelle stabilization was accomplished by binding of model drug (doxorubicin) via an acid-sensitive hydrazone bond and incorporating one to four 11-aminoundecanoic acid (AUA) moieties to manipulate the hydrophobic/hydrophilic ratio. Four micelle-forming unimers have been synthesized and their self-assembly into micelles was evaluated. Size of the micelles could be modified by changing the architecture of the unimers from linear to branched. The stability of the micelles increased with increasing content of AUA moieties. Adsorption of all micelles to hydroxyapatite occurred rapidly. Doxorubicin release occurred at pH 5.5, whereas no release was detected at pH 7.4. Cytotoxicity toward human osteosarcoma Saos-2 cells correlated with drug release data.

Indexed as

MicellesAmino AcidsAspartic AcidBone and BonesBone NeoplasmsCell Line, TumorDoxorubicinDrug CarriersDrug LiberationDurapatiteHumansHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsKineticsOligopeptidesOsteosarcoma11-aminoundecanoic acidAmino AcidsAspartic AcidDoxorubicinDrug CarriersDurapatiteMicellesOligopeptides

Identifiers

PMID25291150
PMCPMC4240342
OpenAlexW2330695668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.