ReviewPhysiology & behavior2014
Channeling satiation: a primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons.
Review in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Stress in Free-Roaming and Shelter-Housed Dogs: A Review of Neurobiological, Physiological and Behavioral Mechanisms Relevant to Welfare Assessment.Animals : an open access journal from MDPI · 2026Review
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Comparison of receptor expression and cholecystokinin signaling between left and right nodose ganglia.American journal of physiology. Cell physiology · 2026Article
- Characterization of NTS-to-VTA projection neurons reveals higher-order synaptic organization and distinct responsiveness to cholecystokinin.The Journal of physiology · 2025Article
- Functionally distinct evoked and spontaneous neurotransmission operate via a shared pool of synaptic vesicles in viscerosensory afferents.The Journal of physiology · 2025Article
- CCK-expressing neurons in the NTS are directly activated by CCK-sensitive C-type vagal afferents.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Principles of synaptic encoding of brainstem circadian rhythms.Experimental physiology · 2024Review
- CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Circadian regulation of glutamate release pathways shapes synaptic throughput in the brainstem nucleus of the solitary tract (NTS).The Journal of physiology · 2023Article
- Regulation of Presynaptic Calcium Channels.Advances in neurobiology · 2023Article
- TRPM3 in Brain (Patho)Physiology.Frontiers in cell and developmental biology · 2021Review
- TRPM3 expression and control of glutamate release from primary vagal afferent neurons.Journal of neurophysiology · 2021Article
- Glutamatergic activation of A1 and A2 noradrenergic neurons in the rat brain stem.Croatian medical journal · 2019Article
- The metabolic role of vagal afferent innervation.Nature reviews. Gastroenterology & hepatology · 2018Review
- Ethyl Vanillin Activates TRPA1.The Journal of pharmacology and experimental therapeutics · 2017Article
- Direct Anandamide Activation of TRPV1 Produces Divergent Calcium and Current Responses.Frontiers in molecular neuroscience · 2017Article
- The Role of the Vagal Nucleus Tractus Solitarius in the Therapeutic Effects of Obesity Surgery and Other Interventional Therapies on Type 2 Diabetes.Obesity surgery · 2016Review
- Genetic and pharmacological evidence for low-abundance TRPV3 expression in primary vagal afferent neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Obesity results from the chronic imbalance between food intake and energy expenditure. To maintain homeostasis, the brainstem nucleus of the solitary tract (NTS) integrates peripheral information from visceral organs and initiates reflex pathways that control food intake and other autonomic functions. This peripheral-to-central neural communication occurs through activation of vagal afferent neurons which converge to form the solitary tract (ST) and synapse with strong glutamatergic contacts onto NTS neurons. Vagal afferents release glutamate containing vesicles via three distinct pathways (synchronous, asynchronous, and spontaneous) providing multiple levels of control through fast synaptic neurotransmission at ST-NTS synapses. While temperature at the NTS is relatively constant, vagal afferent neurons express an array of thermosensitive ion channels named transient receptor potential (TRP) channels. Here we review the evidence that TRP channels pre-synaptically control quantal glutamate release and examine the potential roles of TRP channels in vagally mediated satiety signaling. We summarize the current literature that TRP channels contribute to asynchronous and spontaneous release of glutamate which can distinctly influence the transfer of information across the ST-NTS synapse. In other words, multiple glutamate vesicle release pathways, guided by afferent TRP channels, provide for robust while adaptive neurotransmission and expand our understanding of vagal afferent signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.