ArticleTranslational psychiatry2014
CACNA1C risk variant affects reward responsiveness in healthy individuals.
Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development.Molecular psychiatry · 2016Pooled it
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Reduced Cacna1c Expression Produces Anhedonic Reactions to Palatable Sucrose in Rats: No Interactions With Juvenile or Adult Stress.Genes, brain, and behavior · 2025Article
- CACNA1C Gene rs1006737 Polymorphism Affects Cognitive Performance in Chinese Han Schizophrenia.Neuropsychiatric disease and treatment · 2022Article
- Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type CaMolecular psychiatry · 2020Article
- Contribution of D1R-expressing neurons of the dorsal dentate gyrus and CaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach.Annals of general psychiatry · 2020Review
- Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species.Schizophrenia bulletin · 2019Article
- The Emerging Neurobiology of Bipolar Disorder.Trends in neurosciences · 2018Review
- From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- A genome-wide association study of emotion dysregulation: Evidence for interleukin 2 receptor alpha.Journal of psychiatric research · 2016Article
- L-type CaThe Journal of physiology · 2016Review
- CACNA1C risk variant is associated with increased amygdala volume.European archives of psychiatry and clinical neuroscience · 2016Article
- Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals.Human brain mapping · 2016Article
- Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders.Progress in neurobiology · 2015Review
- The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.eNeuroArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. We investigated whether this risk variant affects reward responsiveness because reward processing is one of the central cognitive-motivational domains implicated in both disorders. In a sample of 164 young, healthy individuals, we show a dose-dependent response, where the rs1006737 risk genotype was associated with blunted reward responsiveness, whereas discriminability did not significantly differ between genotype groups. This finding suggests that the CACNA1C risk locus may have a role in neural pathways that facilitate value representation for rewarding stimuli. Impaired reward processing may be a transdiagnostic phenotype of variation in CACNA1C that could contribute to anhedonia and other clinical features common to both affective and psychotic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.