ArticlePloS one2014
MicroRNA-217 regulates WASF3 expression and suppresses tumor growth and metastasis in osteosarcoma.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 67 citations in OpenAlex.
- Retraction: QKI5mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis.Oncotarget · 2026Article
- Drug resistance related genes in lung adenocarcinoma predict patient prognosis and influence the tumor microenvironment.Scientific reports · 2023Article
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- Retraction: MicroRNA-137 Contributes to Dampened Tumorigenesis in Human Gastric Cancer by Targeting AKT2.PloS one · 2023Article
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- MicroRNA-744-5p suppresses tumorigenesis and metastasis of osteosarcoma through the p38 mitogen-activated protein kinases pathway by targeting transforming growth factor-beta 1.Bioengineered · 2022Article
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- Retraction: MicroRNA-410 Suppresses Migration and Invasion by Targeting MDM2 in Gastric Cancer.PloS one · 2022Article
- Retraction: MicroRNA-503 Acts as a Tumor Suppressor in Osteosarcoma by Targeting L1CAM.PloS one · 2022Article
- Retraction: MicroRNA-217 Regulates WASF3 Expression and Suppresses Tumor Growth and Metastasis in Osteosarcoma.PloS one · 2022Article
- Retraction: MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression.PloS one · 2022Article
- Retraction: MicroRNA-424 Is Down-Regulated in Hepatocellular Carcinoma and Suppresses Cell Migration and Invasion through c-Myb.PloS one · 2022Article
- Retraction: MicroRNA-33b Suppresses Migration and Invasion by Targeting c-Myc in Osteosarcoma Cells.PloS one · 2022Article
- Retraction: MicroRNA-153 Inhibits Osteosarcoma Cells Proliferation and Invasion by Targeting TGF-β2.PloS one · 2022Article
- Retraction: MicroRNA-137 Upregulation Increases Bladder Cancer Cell Proliferation and Invasion by Targeting PAQR3.PloS one · 2022Article
- Retraction: Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7.PloS one · 2022Article
- Circular RNA circANKIB1 promotes the progression of osteosarcoma by regulating miR-217/PAX3 axis.Journal of bone oncology · 2021Article
- Targeting WASF3 Signaling in Metastatic Cancer.International journal of molecular sciences · 2021Review
- LINC01410 accelerated the invasion and proliferation of osteosarcoma by sponging miR-3128.Aging · 2020Article
- MicroRNA-93 targets WASF3 and functions as a metastasis suppressor in breast cancer.Cancer science · 2020Article
Corrections and comments
- Retraction · 2022-06-08Duplication of/in Image · Investigation by Journal/Publisher · Paper Mill · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma is the most common type of primary tumor of bone which mainly affects adolescents and young adults. Osteosarcoma causes large number of deaths because of its complex pathogenesis and resistance to conventional treatment. MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs, causing translational repression or degradation. In this study, we showed that miR-217 was down-regulated in osteosarcoma cell lines and tissues in comparison to that in normal bone cells or tissues. Meanwhile, the lower level of miR-217 was associated with metastasis in clinical osteosarcoma patients. Furthermore, we found that overexpession of miR-217 markedly suppressed cell proliferation, migration, and invasion of osteosarcoma cells. Conversely, the inhibition of miR-217 expression significantly accelerated the cell proliferation, migration, and invasion. Moreover, we identified WASF3 as a novel functional downstream target of miR-217. The ectopic expression of WASF3 can partially reverse the inhibition of cell proliferation and invasion caused by miR-217. Take together, our results demonstrate that miR-217 functions as a tumor-suppressive miRNA and inhibits the osteosarcoma tumorigenesis through targeting WASF3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.