Evidence map›Paper›PMID 25289670›Full record

ArticlePloS one2014

Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

Tatiana Usenko, Gordon Chan, Emina Torlakovic, Ursula Klingmüller, Benjamin G Neel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Role of SHP2 in hematopoiesis and leukemogenesis.Current opinion in hematology · 2017
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Tatiana UsenkoPrincess Margaret Cancer Center, University Health Network, Toronto, Canada.
Gordon ChanPrincess Margaret Cancer Center, University Health Network, Toronto, Canada.
Emina TorlakovicDepartment of Laboratory Hematology, Toronto General Hospital, University Health Network, Toronto, Canada.
Ursula KlingmüllerSystems Biology of Signal Transduction, German Cancer Research Center (DKFZ), DKFZ-ZMBH-Alliance, Heidelberg, Germany.
Benjamin G NeelPrincess Margaret Cancer Center, University Health Network, Toronto, Canada; Departments of Medical Biophysics and Biochemistry, University of Toronto, Toronto, Canada.
German Cancer Research Center · DEPrincess Margaret Cancer Centre · CAToronto General Hospital · CAUniversity Health Network · CAUniversity of Toronto · CA

Funding

Role of Gab2 and Shp2 in Hematopoietic SignallingR01CA114945 · NCI · UNIVERSITY HEALTH NETWORK · PI NEEL, BENJAMIN G. · 2006 to 2010
$1.7M
NCI NIH HHS R01 CA114945NCI NIH HHS R37CA49132
6 · The paper itself

Abstract

Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11, regulates signaling networks and cell fate in many tissues. Expression of oncogenic PTPN11 in the hematopoietic compartment causes myeloproliferative neoplasm (MPN) in humans and mice. However, the stage-specific effect(s) of mutant Ptpn11 on erythroid development have remained unknown. We found that expression of an activated, leukemogenic Ptpn11 allele, Ptpn11D61Y, specifically in the erythroid lineage causes dyserythropoiesis in mice. Ptpn11D61Y progenitors produce excess cKIT+ CD71+ Ter119- cells and aberrant numbers of cKITl° CD71+ erythroblasts. Mutant erythroblasts show elevated activation of ERK, AKT and STAT3 in response to EPO stimulation, and MEK inhibitor treatment blocks Ptpn11D61Y-evoked erythroid hyperproliferation in vitro. Thus, the expression of oncogenic Ptpn11 causes dyserythropoiesis in a cell-autonomous manner in vivo.

Indexed as

Gene Expression Regulation, LeukemicAllelesAnimalsAntigens, CDBone MarrowButadienesCell ProliferationErythroblastsErythropoiesisErythropoietinExtracellular Signal-Regulated MAP KinasesHematopoietic Stem CellsLeukemiaMiceNitrilesProtein Kinase InhibitorsAntigens, CDButadienesCD71 antigenErythropoietinExtracellular Signal-Regulated MAP KinasesNitrilesProtein Kinase InhibitorsProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitPtpn11 protein, mouseReceptors, TransferrinStat3 protein, mouseSTAT3 Transcription FactorU 0126

Identifiers

PMID25289670
PMCPMC4188809
OpenAlexW1995376677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.