ReviewPlastic and reconstructive surgery. Global open2013
The role of wound healing and its everyday application in plastic surgery: a practical perspective and systematic review.
Review in Plastic and reconstructive surgery. Global open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Postoperative Mechanomodulation Decreases T-Junction Dehiscence After Reduction Mammaplasty: Early Scar Analysis From a Randomized Controlled Trial.Aesthetic surgery journal · 2023Trial
- An Update on Post-Surgical Wound Healing Management and Lower-Cost Alternatives: A Narrative Review for Healthcare Providers.Health science reports · 2026Article
- Spontaneous small bowel evisceration through an umbilical region incisional hernia with features suggestive of Richter-type involvement in an HIV-positive patient: a case report.International journal of surgery case reports · 2026Article
- Prolongation of Postoperative Drainage Time in Indocyanine Green Lymphography as a Potential Marker for Lymphedema Development-A Prospective Pilot Study.Journal of clinical medicine · 2026Article
- The impact of transportation on wounds up to 4 cm on umbilical outpouchings of slaughter pigs.Acta veterinaria Scandinavica · 2025Article
- Challenging the Dogma of Dead Space Obliteration With Muscle Flaps in Deep Spinal Surgical Site Infections.Plastic and reconstructive surgery. Global open · 2025Article
- Perioperative Drug Management of Systemic Therapies in Breast Cancer: A Literature Review and Treatment Recommendations.Current oncology (Toronto, Ont.) · 2025Review
- Microneedles: A novel clinical technology for evaluating skin characteristics.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity.Advanced healthcare materials · 2023Article
- Reporting of scar outcomes in the hand and wrist; a state-of-the-art literature review.BMC musculoskeletal disorders · 2023Review
- Obesity and Wound Healing: Focus on Mesenchymal Stem Cells.Life (Basel, Switzerland) · 2023Review
- Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study.Life (Basel, Switzerland) · 2023Article
- Skin biomechanics: a potential therapeutic intervention target to reduce scarring.Burns & trauma · 2022Review
- Biomarkers and heterogeneous fibroblast phenotype associated with incisional hernia.Molecular and cellular biochemistry · 2021Article
- Slowly absorbable mesh in contaminated incisional hernia repair: results of a French multicenter study.Hernia : the journal of hernias and abdominal wall surgery · 2021Article
- Poly-4-hydroxybutyrate (Phasix™) mesh onlay in complex abdominal wall repair.Surgical endoscopy · 2021Article
- Wound Healing Activity of a Novel Formulation SKRIN via Induction of Cell Cycle Progression and Inhibition of PCNA-p21 Complex Interaction Leading to Cell Survival and Proliferation.ACS pharmacology & translational science · 2021Article
- The Combined Effect of Photobiomodulation and Curcumin on Acute Skin Wound Healing in Rats.Journal of lasers in medical sciences · 2021Article
- Pregnancy after abdominoplasty with mesh placement: A case report.JPRAS open · 2020Article
- TGF-β expression and wound tensile strength after simple interrupted suturing and zip surgical skin closure (IN VIVO study).Annals of medicine and surgery (2012) · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter surgery it is often recommended that patients should refrain from strenuous physical activity for 4-6 weeks. This recommendation is based on the time course of wound healing. Here, we present an overview of incisional wound healing with a focus on 2 principles that guide our postoperative recommendations: the gain of tensile strength of a wound over time and the effect of mechanical stress on wound healing.
methodsA systematic search of the English literature was conducted using OVID, Cochrane databases, and PubMed. Inclusion criteria consisted of articles discussing the dynamics of incisional wound healing, and exclusion criteria consisted of articles discussing nonincisional wounds.
resultsExperiments as early as 1929 laid the groundwork for our postoperative activity recommendations. Research using animal models has shown that the gain in tensile strength of a surgical wound is sigmoidal in trajectory, reaching maximal strength approximately 6 weeks postoperatively. Although human and clinical data are limited, the principles gained from laboratory investigation have provided important insights into the relationship among mechanical stress, collagen dynamics, and the time course of wound healing.
conclusionOur postoperative activity recommendations are based on a series of animal studies. Clinical research supporting these recommendations is minimal, with the most relevant clinical data stemming from early motion protocols in the orthopedic literature. We must seek to establish clinical data to support our postoperative activity recommendations so that we can maximize the physiologic relationships between wound healing and mechanical stress.
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Registered trials
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