ArticleCurrent immunology reviews2012
NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation.
Article in Current immunology reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.Cell reports · 2022Article
- Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE.Cellular & molecular immunology · 2019Review
- Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Editorial: Role of CD1- and MR1-Restricted T Cells in Immunity and Disease.Frontiers in immunology · 2019Article
- Advances in NKT cell Immunotherapy for Glioblastoma.Journal of cancer science & therapy · 2018Article
- Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease.Respiratory research · 2017Article
- Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants.Scientific reports · 2017Article
- Natural Killer T Cells in Liver Ischemia-Reperfusion Injury.Journal of clinical medicine · 2017Review
- Donor-unrestricted T cells in the human CD1 system.Immunogenetics · 2016Review
- Natural killer T cells in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis.Immunology · 2015Review
- Innate immunity drives the initiation of a murine model of primary biliary cirrhosis.PloS one · 2015Article
- Imaging of NKT Cell Recirculation and Tissue Migration during Antimicrobial Immunity.Frontiers in immunology · 2015Review
- Synthesis of a 2"-deoxy-β-GalCer.Molecules (Basel, Switzerland) · 2014Article
- Different subsets of natural killer T cells may vary in their roles in health and disease.Immunology · 2014Review
- Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells.Cancer immunity · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The innate-like natural killer T (NKT) cells are essential regulators of immunity. These cells comprise at least two distinct subsets and recognize different lipid antigens presented by the MHC class I like molecules CD1d. The CD1d-dependent recognition pathway of NKT cells is highly conserved from mouse to humans. While most type I NKT cells can recognize αGalCer and express a semi-invariant T cell receptor (TCR), a major population of type II NKT cells reactive to sulfatide utilizes an oligoclonal TCR. Furthermore TCR recognition features of NKT subsets are also distinctive with almost parallel as opposed to perpendicular footprints on the CD1d molecules for the type I and type II NKT cells respectively. Here we present a view based upon the recent studies in different clinical and experimental settings that while type I NKT cells are more often pathogenic, they may also be regulatory. On the other hand, sulfatide-reactive type II NKT cells mostly play an inhibitory role in the control of autoimmune and inflammatory diseases. Since the activity and cytokine secretion profiles of NKT cell subsets can be modulated differently by lipid ligands or their analogs, novel immunotherapeutic strategies are being developed for their differential activation for potential intervention in inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.