ArticleProceedings of the National Academy of Sciences of the United States of America2014
Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 233 citations in OpenAlex.
- Transcription Factor TCP9 EnhancesPlants (Basel, Switzerland) · 2026Article
- Genome-wide analyses of NPF and NRT2 reveal a potential role for a key gene, CqNRT2.2, in the quinoa response to nitrate.BMC plant biology · 2026Article
- Nitrogen-Controlled Host Gatekeeping: Regulatory Chokepoints Across Four Windows for Diazotroph Access.International journal of molecular sciences · 2026Article
- Uncovering the early and conserved molecular mechanisms of root nitrogen foraging in model and crops.BMC genomics · 2026Article
- The transcription factor OsMADS61 positively regulates root elongation and nitrogen use efficiency in rice.Plant communications · 2026Article
- Evolutionary trajectory of the NPF6.3(NRT1.1/CHL1)-centered nitrate signaling regulatory network in plant roots.BMC plant biology · 2025Article
- DSK2-mediated degradation of F-box protein LAO1 and class I TCPs modulates the nitrogen starvation response.EMBO reports · 2025Article
- The Root Development Genes (RDGs) Network inPlants (Basel, Switzerland) · 2025Article
- Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits.The Plant cell · 2025Article
- Effect of Ammonium:Nitrate Application Ratios on Growth and Nitrogen Metabolism of Tea Plants (Plant direct · 2025Article
- Beyond nitrate transport: AtNRT2.4 responds to local and systemic nitrogen signaling in Arabidopsis.BMC plant biology · 2025Article
- Model-to-crop conserved NUE Regulons enhance machine learning predictions of nitrogen use efficiency.The Plant cell · 2025Article
- TaTCP6 is required for efficient and balanced utilization of nitrate and phosphorus in wheat.Nature communications · 2025Article
- The AP2/ERF Transcription Factor ERF56 Negatively Regulating Nitrate-Dependent Plant Growth inInternational journal of molecular sciences · 2025Article
- SnRK1α1-mediated RBOH1 phosphorylation regulates reactive oxygen species to enhance tolerance to low nitrogen in tomato.The Plant cell · 2024Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2024Article
- The clock-associated LUX ARRHYTHMO regulates high-affinity nitrate transport in Arabidopsis roots.The Plant journal : for cell and molecular biology · 2024Article
- The CaGenes · 2024Article
- Transcription factor ZmEREB97 regulates nitrate uptake in maize (Zea mays) roots.Plant physiology · 2024Article
- NIN-like proteins (NLPs) as crucial nitrate sensors: an overview of their roles in nitrogen signaling, symbiosis, abiotic stress, and beyond.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
46 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
To compete for nutrients in diverse soil microenvironments, plants proliferate lateral roots preferentially in nutrient-rich zones. For nitrate, root foraging involves local and systemic signaling; however, little is known about the genes that function in the systemic signaling pathway. By using nitrate enhancer DNA to screen a library of Arabidopsis transcription factors in the yeast one-hybrid system, the transcription factor gene TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR1-20 (TCP20) was identified. TCP20, which belongs to an ancient, plant-specific gene family that regulates shoot, flower, and embryo development, was implicated in nitrate signaling by its ability to bind DNA in more than 100 nitrate-regulated genes. Analysis of insertion mutants of TCP20 showed that they had normal primary and lateral root growth on homogenous nitrate media but were impaired in preferential lateral root growth (root foraging) on heterogeneous media in split-root plates. Inhibition of preferential lateral root growth was still evident in the mutants even when ammonium was uniformly present in the media, indicating that the TCP20 response was to nitrate. Comparison of tcp20 mutants with those of nlp7 mutants, which are defective in local control of root growth but not in the root-foraging response, indicated that TCP20 function is independent of and distinct from NLP7 function. Further analysis showed that tcp20 mutants lack systemic control of root growth regardless of the local nitrate concentrations. These results indicate that TCP20 plays a key role in the systemic signaling pathway that directs nitrate foraging by Arabidopsis roots.
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