ArticleActa biomaterialia2015
A hypothesis-driven parametric study of effects of polymeric scaffold properties on tissue engineered neovessel formation.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Rational design of immunological programs for functional regenerative niches.Materials today. Bio · 2026Review
- Predicted Effects of Patient Variability and Notch Signaling on In Situ Vascular Tissue Engineering.Annals of biomedical engineering · 2026Article
- Platelets: the first cellular responders in the foreign body response to blood-contacting biomaterials.Frontiers in immunology · 2026Review
- Oversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts.JACC. Basic to translational science · 2025Article
- Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts.Journal of biomechanics · 2025Article
- The Influence of Textile Structure Characteristics on the Performance of Artificial Blood Vessels.Polymers · 2023Review
- Reducing retraction in engineered tissues through design of sequential growth factor treatment.Biofabrication · 2023Article
- Tissue Engineering of Vascular Grafts: A Case Report From Bench to Bedside and Back.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Progress in the application of patch materials in cardiovascular surgery.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model.Biomechanics and modeling in mechanobiology · 2022Article
- The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency.Research (Washington, D.C.) · 2022Article
- Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth.Communications medicine · 2022Article
- CCL2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae.Acta biomaterialia · 2021Article
- Constrained Mixture Models of Soft Tissue Growth and Remodeling - Twenty Years After.Journal Of Elasticity · 2021Article
- Review
- Computational models of cardiac hypertrophy.Progress in biophysics and molecular biology · 2021Review
- Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms.Current opinion in biomedical engineering · 2020Review
- Fast, Rate-Independent, Finite Element Implementation of a 3D Constrained Mixture Model of Soft Tissue Growth and Remodeling.Computer methods in applied mechanics and engineering · 2020Article
- A computational bio-chemo-mechanical model of in vivo tissue-engineered vascular graft development.Integrative biology : quantitative biosciences from nano to macro · 2020Article
- Spontaneous reversal of stenosis in tissue-engineered vascular grafts.Science translational medicine · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
Continued advances in the tissue engineering of vascular grafts have enabled a paradigm shift from the desire to design for adequate suture retention, burst pressure and thrombo-resistance to the goal of achieving grafts having near native properties, including growth potential. Achieving this far more ambitious outcome will require the identification of optimal, not just adequate, scaffold structure and material properties. Given the myriad possible combinations of scaffold parameters, there is a need for a new strategy for reducing the experimental search space. Toward this end, we present a new modeling framework for in vivo neovessel development that allows one to begin to assess in silico the potential consequences of different combinations of scaffold structure and material properties. To restrict the number of parameters considered, we also utilize a non-dimensionalization to identify key properties of interest. Using illustrative constitutive relations for both the evolving fibrous scaffold and the neotissue that develops in response to inflammatory and mechanobiological cues, we show that this combined non-dimensionalization computational approach predicts salient aspects of neotissue development that depend directly on two key scaffold parameters, porosity and fiber diameter. We suggest, therefore, that hypothesis-driven computational models should continue to be pursued given their potential to identify preferred combinations of scaffold parameters that have the promise of improving neovessel outcome. In this way, we can begin to move beyond a purely empirical trial-and-error search for optimal combinations of parameters and instead focus our experimental resources on those combinations that are predicted to have the most promise.
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Registered trials
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