Evidence map›Paper›PMID 25288448›Full record

ArticleResearch in social & administrative pharmacy : RSAP

Medication oversupply in patients with diabetes.

Carolyn T Thorpe, Heather Johnson, Anna Legreid Dopp, Joshua M Thorpe, Katie Ronk, Christine M Everett, Mari Palta, David A Mott, Betty Chewning, Loren Schleiden and 1 more

Abstract read
In one paragraph

Article in Research in social & administrative pharmacy : RSAP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Rural-urban disparities in diabetes quality of care with accountable care organization participation.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026
    Article
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  8. Approaches to Supporting the Analysis of Historical Medication Datasets with RxNorm.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Carolyn T ThorpeCenter for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, University Drive (151C), Building 30, Pittsburgh, PA 15240-1001, USA; Department of Pharmacy and Therapeutics, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA. Electronic address: ctthorpe@pitt.edu.
Heather JohnsonDepartment of Medicine, University of Wisconsin, 800 University Bay Drive, Suite 210, Madison, WI 53705, USA.
Anna Legreid DoppPharmacy Society of Wisconsin, 701 Heartland Trail, Madison, WI 53717, USA.
Joshua M ThorpeCenter for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, University Drive (151C), Building 30, Pittsburgh, PA 15240-1001, USA; Department of Pharmacy and Therapeutics, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA.
Katie RonkDepartment of Population Health Sciences, University of Wisconsin, 800 University Bay Drive, Suite 210, Madison, WI 53705, USA.
Christine M EverettDepartment of Community and Family Medicine, Duke University Medical Center, 318 Hanes House, DUMC 2914, Durham, NC 27710, USA.
Mari PaltaDepartment of Population Health Sciences, University of Wisconsin, 800 University Bay Drive, Suite 210, Madison, WI 53705, USA.
David A MottSchool of Pharmacy, University of Wisconsin, 777 Highland Drive, Madison, WI 53705, USA.
Betty ChewningSchool of Pharmacy, University of Wisconsin, 777 Highland Drive, Madison, WI 53705, USA.
Loren SchleidenDepartment of Pharmacy and Therapeutics, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA.
Maureen A SmithDepartment of Population Health Sciences, University of Wisconsin, 800 University Bay Drive, Suite 210, Madison, WI 53705, USA; Department of Family Medicine, University of Wisconsin, 800 University Bay Drive, Suite 210, Madison, WI 53705, USA; Department of Surgery, University of Wisconsin, 800 University Bay Drive, Suite 210, Madison, WI 53705, USA.
University of Wisconsin–Madison · USUniversity of Pittsburgh · USDuke Medical Center · USHighland Community College - Illinois · USVA Pittsburgh Healthcare System · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Guideline Adherence and Short/Long-term Health Outcomes in Patients with DiabetesR01HS018368 · AHRQ · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, MAUREEN A · 2009 to 2013
$2.3M
POPULATION-BASED HEALTH SERVICES RESEARCH TRAININGT32HS000083 · AHRQ · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, MAUREEN A · 1998 to 2012
$2.0M
Identifying and Addressing Barriers to Hypertension Control in Young AdultsK23HL112907 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, HEATHER M · 2012 to 2016
$845k
Medication Oversupply and Outcomes in Patients with DiabetesR21DK090634 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI THORPE, CAROLYN TIMBERLAKE · 2010 to 2011
$410k
Guideline Adherence and Health Outcomes in Medicare FFS Patients with DiabetesR21HS017646 · AHRQ · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, MAUREEN A · 2008 to 2009
$312k
AHRQ HHS 5T32HS000083AHRQ HHS HS000083-12AHRQ HHS R01 HS018368AHRQ HHS R01HS018368AHRQ HHS R21 HS017646AHRQ HHS R21HS017646AHRQ HHS T32 HS000083NCATS NIH HHS 9U54TR000021NCATS NIH HHS UL1 TR000427NCRR NIH HHS 1UL1RR025011NCRR NIH HHS UL1 RR025011NHLBI NIH HHS 1K23HL112907NHLBI NIH HHS K23 HL112907NIDDK NIH HHS R21 DK090634NIDDK NIH HHS R21DK090634
6 · The paper itself

Abstract

backgroundStudies in integrated health systems suggest that patients often accumulate oversupplies of prescribed medications, which is associated with higher costs and hospitalization risk. However, predictors of oversupply are poorly understood, with no studies in Medicare Part D.

objectiveThe aim of this study was to describe prevalence and predictors of oversupply of antidiabetic, antihypertensive, and antihyperlipidemic medications in adults with diabetes managed by a large, multidisciplinary, academic physician group and enrolled in Medicare Part D or a local private health plan.

methodsThis was a retrospective cohort study. Electronic health record data were linked to medical and pharmacy claims and enrollment data from Medicare and a local private payer for 2006-2008 to construct a patient-quarter dataset for patients managed by the physician group. Patients' quarterly refill adherence was calculated using ReComp, a continuous, multiple-interval measure of medication acquisition (CMA), and categorized as <0.80 = Undersupply, 0.80-1.20 = Appropriate Supply, >1.20 = Oversupply. We examined associations of baseline and time-varying predisposing, enabling, and medical need factors to quarterly supply using multinomial logistic regression.

resultsThe sample included 2519 adults with diabetes. Relative to patients with private insurance, higher odds of oversupply were observed in patients aged <65 in Medicare (OR = 3.36, 95% CI = 1.61-6.99), patients 65+ in Medicare (OR = 2.51, 95% CI = 1.37-4.60), patients <65 in Medicare/Medicaid (OR = 4.55, 95% CI = 2.33-8.92), and patients 65+ in Medicare/Medicaid (OR = 5.73, 95% CI = 2.89-11.33). Other factors associated with higher odds of oversupply included any 90-day refills during the quarter, psychotic disorder diagnosis, and moderate versus tight glycemic control.

conclusionsOversupply was less prevalent than in previous studies of integrated systems, but Medicare Part D enrollees had greater odds of oversupply than privately insured individuals. Future research should examine utilization management practices of Part D versus private health plans that may affect oversupply.

Indexed as

AgedAge FactorsAntihypertensive AgentsCohort StudiesDiabetes MellitusDrug PrescriptionsDrug UtilizationElectronic Health RecordsFemaleHumansHypoglycemic AgentsHypolipidemic AgentsInternational Classification of DiseasesMaleMedicare Part DMedication AdherenceAntihypertensive AgentsHypoglycemic AgentsHypolipidemic AgentsPrescription DrugsDiabetesMedication surplusOversupplyRefill adherence

Identifiers

PMID25288448
PMCPMC4362914
OpenAlexW2091804519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.