Evidence map›Paper›PMID 25288136›Full record

SynthesisMolecular psychiatry2015

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

Coffee and Caffeine Genetics Consortium, Marilyn C Cornelis, Enda M Byrne, Tõnu Esko, Michael A Nalls, Andrea Ganna, Nina Paynter, Keri L Monda, Najaf Amin, Krista Fischer and 148 more

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  20. Genetic Variation in Steroid and Xenobiotic Metabolizing Pathways and Enterolactone Excretion Before and After Flaxseed Intervention in African American and European American Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Trial

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

158 authors.

Coffee and Caffeine Genetics Consortium
Marilyn C CornelisChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Enda M Byrne *The University of Queensland, Queensland Brain Institute, Queensland, Australia.
Tõnu Esko *Estonian Genome Center, University of Tartu, Tartu, Estonia.
Michael A Nalls *Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Andrea GannaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska, Sweden.
Nina PaynterDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Keri L MondaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Najaf AminDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Krista FischerEstonian Genome Center, University of Tartu, Tartu, Estonia.
Frida RenstromDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Julius S NgwaDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Ville HuikariInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Alana CavadinoCentre for Paediatric Epidemiology and Biostatistics, Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Alexander TeumerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
Kai YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Pedro Marques-VidalInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Rajesh RawalInstitute of Genetic Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Mary K WojczynskiWashington University School of Medicine, Department of Genetics, Division of Statistical Genomics, St Louis, Missouri, USA.
Jacqueline M VinkDepartment of Biological Psychology / Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Jing Hua ZhaoMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
George BurlutskyCentre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, New South Wales, Australia.
Jari LahtiInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Vera MikkiläDepartment of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Joel ErikssonCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Solomon K MusaniUniversity of Mississippi Medical Center, Jackson, Mississippi, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Frank GellerStatens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Jian'an LuanMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Jennie HuiBusselton Population Medical Research Foundation Inc., Busselton, Australia.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Maria DimitriouHarokopio University, Athens, Greece.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA.
Weang-Kee HoDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Margaret J WrightQIMR Berghofer Medical Research Institute, Queensland, Australia.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Patrik Ke MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska, Sweden.
David CouperDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ben A OostraDepartment of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Mohammad Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Henning W TiemeierDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Andre G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Frank Ja van RooijDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Inês BarrosoWellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Ingegerd JohanssonDepartment of Odontology, Umeå University, Umeå, Sweden.
Luting XueDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Marika KaakinenInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Chris PowerCentre for Paediatric Epidemiology and Biostatistics, Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Ronald P StolkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Sebastian E BaumeisterInstitute for Community Medicine, University Medicine Greifswald, Germany.
Reiner BiffarDepartment of Prosthodontics, Gerodontology and Biomaterials, Center of Oral Health, University Medicine Greifswald, Germany.
Fangyi GuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
François BastardotDepartment of Internal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Zoltán KutalikDepartment of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Nita G ForouhiMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Lars LindDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Cecilia LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Karl MichaëlssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Andrew MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Majken JensenDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Kay-Tee KhawDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Robert N LubenDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Jie Jin WangCentre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, New South Wales, Australia.
Satu MännistöDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Mia-Maria PeräläDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and School of Medicine University of Tampere, Tampere, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and School of Medicine, University of Tampere, Tampere, Finland.
Jorma ViikariDepartment of Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Dariush MozaffarianChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kenneth MukamalBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Angela DöringInstitute of Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
Andrew C HeathDepartment of Psychiatry, Washington University, St.Louis, Missouri, USA.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Queensland, Australia.
Norbert DahmenDepartment for Psychiatry, Johannes-Gutenberg-University, Mainz, Germany.
Teresa CarithersSchool of Applied Sciences, University of Mississippi, Oxford, Mississippi, USA.
Katherine L TuckerClinical Laboratory & Nutritional Sciences, University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Heather A BoydStatens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Mads MelbyeStatens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Jorien L TreurDepartment of Biological Psychology / Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Dan MellströmCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Jouke Jan HottengaDepartment of Biological Psychology / Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Inga ProkopenkoWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Anke TönjesMedical Department, University of Leipzig, Germany.
Panos DeloukasWellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Mattias LorentzonCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Denise K HoustonWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Yongmei LiuWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
John DaneshDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Asif RasheedCenter for Non-Communicable Diseases, Pakistan.
Marc A MasonHealth Disparities Research Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Alan B ZondermanLaboratory of Personality and Cognition, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bruce S KristalDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
International Parkinson’s Disease Genomics Consortium (IPDGC)
North American Brain Expression Consortium (NABEC)
UK Brain Expression Consortium (UKBEC)
Juha KarjalainenDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Danielle R ReedMonell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Harm-Jan WestraDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Michele K EvansHealth Disparities Research Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Danish SaleheenDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA.
George DedoussisHarokopio University, Athens, Greece.
Gary CurhanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Michael StumvollMedical Department, University of Leipzig, Germany.
John BeilbyBusselton Population Medical Research Foundation Inc., Busselton, Australia.
Louis R PasqualeChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bjarke FeenstraStatens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
Jose M OrdovasJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Andrew T ChanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Claes OhlssonCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Queensland, Australia.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
David S SiscovickCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Johan G ErikssonFolkhälsan Research Centre, Helsinki, Finland.
Paul MitchellCentre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, New South Wales, Australia.
David J HunterChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA.
Eric B RimmChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dorret I BoomsmaDepartment of Biological Psychology / Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Ingrid B BoreckiWashington University School of Medicine, Department of Genetics, Division of Statistical Genomics, St Louis, Missouri, USA.
Ruth Jf LoosMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Nicholas J WarehamMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Peter VollenweiderDepartment of Internal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Germany.
Marian L NeuhouserFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Bruce Hr WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Frank B HuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Elina HyppönenCentre for Paediatric Epidemiology and Biostatistics, Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK.
Marjo-Riitta JärvelinInstitute of Health Sciences, University of Oulu, Oulu, Finland.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Paul W FranksDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Gerardo HeissDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Jennifer A NettletonDivision of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Rob M van DamSaw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

STATISTICSP50HL105185 · NHLBI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI TUCKER, KATHERINE L · 2010 to 2015
$10.4M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Resource CoreP60AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2009 to 2013
$8.8M
Gene-Environment Interactions in GlaucomaR01EY015473 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2005 to 2021
$8.3M
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
MECHANISMS OF DEEP BRAIN STIMULATIONR01NS041509 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2015
$6.8M
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0M
Probing The Dark Matter of the Genome in the NHLBI Family Heart StudyR01HL117078 · NHLBI · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2013 to 2016
$3.0M
Genes and Environment Initiative in GlaucomaU01HG004728 · NHGRI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2008 to 2009
$1.0M
British Heart Foundation RG/08/014/24067British Heart Foundation RG/13/13/30194Cancer Research UK 14136Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_U106179471Medical Research Council MC_UP_A100_1003Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5Medical Research Council MR/L003120/1NCI NIH HHS UM1 CA182913NEI NIH HHS R01 EY015473NHGRI NIH HHS U01 HG004728NHLBI NIH HHS P50 HL105185NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL120393NIAAA NIH HHS P60 AA011998NINDS NIH HHS R01 NS041509NINDS NIH HHS R01 NS075321Wellcome Trust 090532
6 · The paper itself

Abstract

Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log10Bayes factor (BF)>5.64) with per-allele effect sizes of 0.03-0.14 cups per day. Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine. Two map to GCKR and MLXIPL genes related to metabolic traits but lacking known roles in coffee consumption. Enhancer and promoter histone marks populate the regions of many confirmed loci and several potential regulatory SNPs are highly correlated with the lead SNP of each. SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smoking initiation, higher adiposity and fasting insulin and glucose but lower blood pressure and favorable lipid, inflammatory and liver enzyme profiles (P<5 × 10(-8)).Our genetic findings among European and African-American adults reinforce the role of caffeine in mediating habitual coffee consumption and may point to molecular mechanisms underlying inter-individual variability in pharmacological and health effects of coffee.

Indexed as

Feeding BehaviorGenome-Wide Association StudyAdaptor Proteins, Signal TransducingBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBrain-Derived Neurotrophic FactorCoffeaCytochrome P-450 CYP1A2HumansPhenotypePolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBrain-Derived Neurotrophic FactorCytochrome P-450 CYP1A2GCKR protein, humanMLXIPL protein, human

Identifiers

PMID25288136
PMCPMC4388784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.