ReviewClinical journal of the American Society of Nephrology : CJASN2015
Renal control of calcium, phosphate, and magnesium homeostasis.
Review in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06026527 (Intra-operative Magnesium Sulphate for Post-operative Pain in Patients Undergoing Total Abdominal Hysterectomy Under General Anesthesia), which is not on this map. Cited by 316 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intra-operative Magnesium Sulphate for Post-operative Pain in Patients Undergoing Total Abdominal Hysterectomy Under General Anesthesia
Who cites it
316 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.Frontiers in nutrition · 2022Pooled it
- Open-label extension of a randomized trial investigating safety and efficacy of rhPTH(1-84) in hypoparathyroidism.JBMR plus · 2024Trial
- Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults.The Journal of nutrition · 2021Trial
- Gut Microbiota as a Molecular Regulator of Mineral Homeostasis in Horses: Mechanisms and Future Perspectives.International journal of molecular sciences · 2026Review
- Comparative Analysis of Selected Biochemical Markers Involved in Antioxidative, Immune Responses, and Thyroid Function in Wistar Rats Fed Diets Containing Baked Sprats.Molecules (Basel, Switzerland) · 2026Article
- Synergistic Effects of Magnesium Ions and Hydrogen Gas in Biodegradable Mg Implants: Mechanisms, Therapeutic Windows, and Translational Perspectives.Annals of biomedical engineering · 2026Review
- EP3 receptor mediates calcium oxalate kidney stone formation via Ca²⁺/AKT and necroinflammation.Urolithiasis · 2026Article
- Loss ofbioRxiv : the preprint server for biology · 2026Article
- Growth performance, intestinal morphology, and serum biochemistry of European quail (Coturnix coturnix) fed agro-industrial fruit residue extracts as alternatives to antibiotic growth promoters.Poultry science · 2026Article
- A comparative analysis of metabolic and urinary bacterial culture profiles between patients with staghorn and non-staghorn infectious renal stones.BMC nephrology · 2026Article
- Short-term mortality prediction based on biochemical blood markers in azotemic cattle with renal disease.Journal of veterinary internal medicine · 2026Article
- Hypophosphatemia in kidney stone formers.Current opinion in nephrology and hypertension · 2026Review
- Thiazide therapy in chronic hypoparathyroidism: effects on hypercalciuria and renal function-a systematic review and exploratory meta-analysis.Journal of endocrinological investigation · 2026Review
- Diuretic-Induced Hypomagnesemia May Play a Key Role in the Development of Calcium Pyrophosphate Arthritis.Rheumatology and therapy · 2026Article
- The impact of magnesium levels in pregnancy on adverse birth outcomes: a protocol for a systematic review and meta-analysis.Systematic reviews · 2026Article
- Comparing 24 h Urine and Spot Urine Calcium Measurements in Clinical Routine: Accuracy and Limitations.Journal of clinical medicine · 2026Article
- Mineralocorticoid Receptor Antagonists in Chronic Kidney Disease: Clinical Evidence, Pharmacology, and Drug-Drug Interactions for Personalized Management of Hyperkalemia.International journal of molecular sciences · 2026Review
- Renal tubular calcium phosphate microcrystallopathy and age-related kidney function decline: The Aging Kidney Study.Clinical kidney journal · 2026Article
- Positive association between serum calcium-phosphorus ratio and kidney stone prevalence: Analysis of NHANES data (2007-2020).Medicine · 2026Article
- Lumpy Skin Disease Virus (LSDV) recently emerged in Egypt: molecular detection, and assessment of the related hematobiochemical, and risk factors.BMC veterinary research · 2026Article
256 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels. Renal regulation of these ions occurs through glomerular filtration and tubular reabsorption and/or secretion and is therefore an important determinant of plasma ion concentration. Under physiologic conditions, the whole body balance of calcium, phosphate, and magnesium is maintained by fine adjustments of urinary excretion to equal the net intake. This review discusses how calcium, phosphate, and magnesium are handled by the kidneys.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.