ArticleInfection and immunity2014
Contribution of the interaction of Streptococcus mutans serotype k strains with fibrinogen to the pathogenicity of infective endocarditis.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Evaluation of Streptococcus mutans strains possessing genes encoding collagen-binding proteins in the Japanese population.BMC oral health · 2025Article
- Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children.Scientific reports · 2025Article
- Review
- Cell wall glycosyltransferase ofInfection and immunity · 2025Article
- Contribution of collagen-binding protein Cnm of Streptococcus mutans to induced IgA nephropathy-like nephritis in rats.Communications biology · 2024Article
- Roles ofFrontiers in microbiology · 2024Review
- Inhibitory Effect of Adsorption ofInternational journal of molecular sciences · 2023Article
- The systemic oral health connection: Biofilms.Medicine · 2022Review
- Anti-Adherence and Antimicrobial Activities of Silver Nanoparticles against SerotypesMedicina (Kaunas, Lithuania) · 2022Article
- Evaluation of the collagen-binding properties and virulence of killed Streptococcus mutans in a silkworm model.Scientific reports · 2022Article
- Article
- Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions.Clinical and experimental nephrology · 2020Article
- Potential involvement of Streptococcus mutans possessing collagen binding protein Cnm in infective endocarditis.Scientific reports · 2020Article
- Contribution of Severe Dental Caries Induced by Streptococcus mutans to the Pathogenicity of Infective Endocarditis.Infection and immunity · 2020Article
- Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort.Open forum infectious diseases · 2020Article
- Calcific Aortic Valve Disease-Natural History and Future Therapeutic Strategies.Frontiers in pharmacology · 2020Review
- Article
- Streptococcus mutans serotypes and collagen-binding proteins Cnm/Cbm in children with caries analysed by PCR.Molecular oral microbiology · 2019Article
- Contribution of Streptococcus mutans Strains with Collagen-Binding Proteins in the Presence of Serum to the Pathogenesis of Infective Endocarditis.Infection and immunity · 2017Article
- Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development.EBioMedicine · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mutans, a pathogen responsible for dental caries, is occasionally isolated from the blood of patients with bacteremia and infective endocarditis (IE). Our previous study demonstrated that serotype k-specific bacterial DNA is frequently detected in S. mutans-positive heart valve specimens extirpated from IE patients. However, the reason for this frequent detection remains unknown. In the present study, we analyzed the virulence of IE from S. mutans strains, focusing on the characterization of serotype k strains, most of which are positive for the 120-kDa cell surface collagen-binding protein Cbm and negative for the 190-kDa protein antigen (PA) known as SpaP, P1, antigen I/II, and other designations. Fibrinogen-binding assays were performed with 85 clinical strains classified by Cbm and PA expression levels. The Cbm(+)/PA(-) group strains had significantly higher fibrinogen-binding rates than the other groups. Analysis of platelet aggregation revealed that SA31, a Cbm(+)/PA(-) strain, induced an increased level of aggregation in the presence of fibrinogen, while negligible aggregation was induced by the Cbm-defective isogenic mutant SA31CBD. A rat IE model with an artificial impairment of the aortic valve created using a catheter showed that extirpated heart valves in the SA31 group displayed a prominent vegetation mass not seen in those in the SA31CBD group. These findings could explain why Cbm(+)/PA(-) strains are highly virulent and are related to the development of IE, and the findings could also explain the frequent detection of serotype k DNA in S. mutans-positive heart valve clinical specimens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.