Evidence map›Paper›PMID 25287914›Full record

ArticleWorld journal of surgery2015

Risk factors for malignancy in branched-type intraductal papillary mucinous neoplasms of the pancreas during the follow-up period.

Yuichiro Kato, Shinichiro Takahashi, Naoto Gotohda, Masaru Konishi

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Article in World journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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3 · Its place in the literature

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6 citing papers in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Yuichiro KatoDivision of Hepatobiliary Pancreatic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan, yuikato@east.ncc.go.jp.
Shinichiro Takahashi
Naoto Gotohda
Masaru Konishi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas were revised in 2012 Tanaka (Pancreatology 12(3):183-197, 2012), making the indications for operation less aggressive. Therefore, the number of branch duct-type IPMN (BD-IPMN) patients requiring follow-up care is expected to increase in the future.

methodsThe aim of this study was to identify risk factors for malignancy in BD-IPMN patients during the follow-up period. This study included 47 BD-IPMN patients without a mural nodule (MN) at the time of initial diagnosis and who subsequently underwent resection after a follow-up period of more than 3 months. Data for the patients were reviewed retrospectively, and the clinicopathological factors were investigated.

resultsIn a univariate analysis, age (≧ 65 years), an increase in the main pancreatic duct (MPD) diameter, the MPD diameter at resection (≧ 5 mm), and the occurrence of MN were significantly associated with malignancy. The occurrence of MN was the only significant factor in a multivariate analysis. In addition, 7 of the 17 patients (41.2 %) who only exhibited an increase in the cyst diameter during the follow-up period were diagnosed as having malignancies. All 6 patients who exhibited an increase in the cyst diameter of 100 % or more were diagnosed as having carcinoma.

conclusionsDuring the follow-up period, the incidence of malignancy was higher among patients with BD-IPMNs and the occurrence of MN, an increase in the MPD diameter, or an increase ratio of 100 % or more in cyst diameter than the others; resection was recommended for these patients.

Indexed as

Adenocarcinoma, MucinousAgedCarcinoma, Pancreatic DuctalFemaleFollow-Up StudiesHumansMaleMiddle AgedMultivariate AnalysisPancreatic CystPancreatic DuctsPancreatic NeoplasmsRetrospective StudiesRisk Factors

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.