ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Individual prediction of heart failure among childhood cancer survivors.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 7 pooled it
28.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 7 syntheses or guidelines pooled it, 270 citations in OpenAlex.
- Risk prediction models for cancer therapy related cardiac dysfunction in patients with cancer and cancer survivors: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2025Pooled it
- Adverse Physical Health Outcomes and Healthcare Service Utilization in Siblings of Children With Cancer: A Systematic Review.Cancer medicine · 2025Pooled it
- Heart failure in long-term survivors of childhood cancer - a systematic review and meta-analysis of population-based studies.Acta oncologica (Stockholm, Sweden) · 2025Pooled it
- Influence of genetic biomarkers on cardiac diseases in childhood cancer survivors: a systematic review.The pharmacogenomics journal · 2025Pooled it
- Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines.The Cochrane database of systematic reviews · 2022Pooled it
- Asymptomatic systolic dysfunction on contemporary echocardiography in anthracycline-treated long-term childhood cancer survivors: a systematic review.Journal of cancer survivorship : research and practice · 2022Pooled it
- Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association.Circulation · 2019Guideline
- Counseling and Cardiovascular Disease Risk Factor Control in Long-Term Cancer Survivors: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Experiences of adult survivors of childhood cancer in a randomized cardiovascular health promotion trial: a qualitative report from the Childhood Cancer Survivor Study.Journal of cancer survivorship : research and practice · 2024Trial
- Primary Care Utilization and Cardiovascular Screening in Adult Survivors of Childhood Cancer.JAMA network open · 2023Trial
- Underdiagnosis and Undertreatment of Modifiable Cardiovascular Risk Factors Among Survivors of Childhood Cancer.Journal of the American Heart Association · 2022Trial
- Late health outcomes after dexrazoxane treatment: A report from the Children's Oncology Group.Cancer · 2022Trial
- Prediction of cardiovascular disease among hematopoietic cell transplantation survivors.Blood advances · 2018Trial
- Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Estimation of Detailed Cardiac Doses for Pediatric Radiation Therapy Patients in National Wilms Tumor Study.International journal of radiation oncology, biology, physics · 2026Article
- The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross-Sectional Study.Pediatric blood & cancer · 2026Observational
- Long-term adverse effects of modern Wilms tumour therapies: implications for monitoring.Nature reviews. Urology · 2026Review
- Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study.European heart journal · 2026Article
- Pharmacogenomic predictors of anthracycline-induced cardiotoxicity in breast cancer patients: a systematic review and meta-analysis.Cardio-oncology (London, England) · 2026Review
- Early Echocardiographic and Serum Biomarkers Predict Thrombotic Microangiopathy, Endotheliopathy, and Survival After Pediatric Hematopoietic Stem Cell Transplant.Transplantation and cellular therapy · 2026Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 1 institution in 1 country.
Eric J ChowEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX. ericchow@u.washington.edu.
Yan ChenEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Leontien C KremerEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Norman E BreslowEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Melissa M HudsonEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Gregory T ArmstrongEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
William L BorderEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Elizabeth A M FeijenEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Daniel M GreenEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Lillian R MeachamEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Kathleen A MeeskeEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Daniel A MulrooneyEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Kirsten K NessEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Kevin C OeffingerEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Charles A SklarEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Marilyn StovallEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Helena J van der PalEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Rita E WeathersEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Leslie L RobisonEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Yutaka YasuiEric J. Chow and Norman E. Breslow, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, WA; Yan Chen and Yutaka Yasui, University of Alberta, Edmonton, Alberta, Canada; Leontien C. Kremer, Elizabeth A.M. Feijen, and Helena J. van der Pal, Emma Children's Hospital and Academic Medical Center, Amsterdam, the Netherlands; Melissa M. Hudson, Gregory T. Armstrong, Daniel M. Green, Daniel A. Mulrooney, Kirsten K. Ness, and Leslie L. Robison, St Jude Children's Research Hospital; Daniel A. Mulrooney, University of Tennessee, Memphis, TN; William L. Border and Lillian R. Meacham, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kathleen A. Meeske, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA; Kevin C. Oeffinger and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY; and Marilyn Stovall and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX.
Radiation Oncology Associates · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Gregory Armstrong · 1985 to 2026
$166.9MMach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7MThe St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9MLate Effects of Treatment in Wilms Tumor Survivors and OffspringR01CA054498 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEISENRING, WENDY M · 1991 to 2017
$13.8MDeterminants of late cardiovascular morbidity among survivors of hematopoietic ceK07CA151775 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHOW, ERIC JESSEN · 2011 to 2015
$755kNCI NIH HHS K07 CA151775NCI NIH HHS P30 CA021765NCI NIH HHS P30 CA21765NCI NIH HHS R01 CA054498NCI NIH HHS U01 CA195547NCI NIH HHS U24 CA055727NCI NIH HHS U24 CA55727
Abstract
purposeTo create clinically useful models that incorporate readily available demographic and cancer treatment characteristics to predict individual risk of heart failure among 5-year survivors of childhood cancer. PATIENTS AND
methodsSurvivors in the Childhood Cancer Survivor Study (CCSS) free of significant cardiovascular disease 5 years after cancer diagnosis (n = 13,060) were observed through age 40 years for the development of heart failure (ie, requiring medications or heart transplantation or leading to death). Siblings (n = 4,023) established the baseline population risk. An additional 3,421 survivors from Emma Children's Hospital (Amsterdam, the Netherlands), the National Wilms Tumor Study, and the St Jude Lifetime Cohort Study were used to validate the CCSS prediction models.
resultsHeart failure occurred in 285 CCSS participants. Risk scores based on selected exposures (sex, age at cancer diagnosis, and anthracycline and chest radiotherapy doses) achieved an area under the curve of 0.74 and concordance statistic of 0.76 at or through age 40 years. Validation cohort estimates ranged from 0.68 to 0.82. Risk scores were collapsed to form statistically distinct low-, moderate-, and high-risk groups, corresponding to cumulative incidences of heart failure at age 40 years of 0.5% (95% CI, 0.2% to 0.8%), 2.4% (95% CI, 1.8% to 3.0%), and 11.7% (95% CI, 8.8% to 14.5%), respectively. In comparison, siblings had a cumulative incidence of 0.3% (95% CI, 0.1% to 0.5%).
conclusionUsing information available to clinicians soon after completion of childhood cancer therapy, individual risk for subsequent heart failure can be predicted with reasonable accuracy and discrimination. These validated models provide a framework on which to base future screening strategies and interventions.
Indexed as
NeoplasmsAdolescentAdultAntineoplastic AgentsArea Under CurveChildChild, PreschoolCohort StudiesFemaleHeart FailureHumansIncidenceMaleNetherlandsNorth AmericaPoisson DistributionAntineoplastic Agents
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