SynthesisPsychological science2014
Replicability and robustness of genome-wide-association studies for behavioral traits.
Synthesis in Psychological science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Shared genetic architectures of educational attainment in East Asian and European populations.Nature human behaviour · 2024Pooled it
- Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Pooled it
- Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups.Genetics · 2026Article
- Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia.Translational psychiatry · 2026Article
- Multimodal deep learning approaches for improving polygenic risk scores with imaging data.Scientific reports · 2026Article
- The long-term associations of perinatal obesogenic environment with offspring biological aging.American journal of epidemiology · 2025Article
- Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways.Frontiers in pharmacology · 2025Article
- Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multi-organ imaging-derived polygenic indexes for brain and body health.medRxiv : the preprint server for health sciences · 2024Article
- Exploring the Fetal Origins Hypothesis Using Genetic Data.Social forces; a scientific medium of social study and interpretation · 2024Article
- Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking.Journal Of Economic Psychology · 2023Article
- The identification of mediating effects using genome-based restricted maximum likelihood estimation.PLoS genetics · 2023Article
- Resource profile and user guide of the Polygenic Index Repository.Nature human behaviour · 2021Article
- Interaction Between Physical Activity and Polygenic Score on Type 2 Diabetes Mellitus in Older Black and White Participants From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Genetic influences on the interactionist model of socioeconomic development: Incorporating polygenic scores for educational attainment into developmental research using the Family Transitions Project (FTP).Developmental psychology · 2021Article
- Article
- The Interplay between Maternal Smoking and Genes in Offspring Birth Weight.medRxiv : the preprint server for health sciences · 2020Article
- Separating Measured Genetic and Environmental Effects: Evidence Linking Parental Genotype and Adopted Child Outcomes.Behavior genetics · 2020Article
- Development and change in attachment: A multiwave assessment of attachment and its correlates across childhood and adolescence.Journal of personality and social psychology · 2020Article
- Genes, Education, and Labor Market Outcomes: Evidence from the Health and Retirement Study.Journal of the European Economic Association · 2020Article
Corrections and comments
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Authors and funding
26 authors.
Funding
Abstract
A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each R (2) ≈ 0.02%), reached genome-wide significance (p < 5 × 10(-8)) in a large discovery sample and were replicated in an independent sample (p < .05). The study also reported associations between educational attainment and indices of SNPs called "polygenic scores." In three studies, we evaluated the robustness of these findings. Study 1 showed that the associations with all three SNPs were replicated in another large (N = 34,428) independent sample. We also found that the scores remained predictive (R (2) ≈ 2%) in regressions with stringent controls for stratification (Study 2) and in new within-family analyses (Study 3). Our results show that large and therefore well-powered genome-wide-association studies can identify replicable genetic associations with behavioral traits. The small effect sizes of individual SNPs are likely to be a major contributing factor explaining the striking contrast between our results and the disappointing replication record of most candidate-gene studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.