ArticleAngewandte Chemie (International ed. in English)2014
Crowning proteins: modulating the protein surface properties using crown ethers.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- 18-Crown-6-ether Utilizes Distinct Allosteric Interactions to Uncouple Transport by the Multidrug Efflux Pump EmrE.Biochemistry · 2025Article
- Modular protein frameworks via supramolecular synthons.Biophysical reviews · 2025Review
- Making and Breaking Supramolecular Synthons for Modular Protein Frameworks.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Hemoglobin Variants as Targets for Stabilizing Drugs.Molecules (Basel, Switzerland) · 2025Review
- Supramolecular Synthons in Protein-Ligand Frameworks.Crystal growth & design · 2024Article
- Atomic-Scale View of Protein-PEG Interactions that Redirect the Thermal Unfolding Pathway of PEGylated Human Galectin-3.Angewandte Chemie (International ed. in English) · 2022Article
- Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group.Communications chemistry · 2022Article
- Exploring the Binding Mechanism of a Supramolecular Tweezer CLR01 to 14-3-3σ ProteinFrontiers in chemistry · 2022Article
- Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate-dependent autoproteolysis activity.IUBMB life · 2021Article
- Structural basis of polyethylene glycol recognition by antibody.Journal of biomedical science · 2020Article
- Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors.Drug design, development and therapy · 2020Review
- Article
- Increasing Performance and Thermostability of D-Phenylglycine Aminotransferase in Miscible Organic Solvents.Iranian journal of biotechnology · 2018Article
- Supramolecular Chemistry Targeting Proteins.Journal of the American Chemical Society · 2017Article
- Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer.Nature communications · 2017Article
- Article
- The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein.PloS one · 2017Article
- The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA.PloS one · 2017Article
- Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination.PloS one · 2016Article
- Structure of a PEGylated protein reveals a highly porous double-helical assembly.Nature chemistry · 2015Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crown ethers are small, cyclic polyethers that have found wide-spread use in phase-transfer catalysis and, to a certain degree, in protein chemistry. Crown ethers readily bind metallic and organic cations, including positively charged amino acid side chains. We elucidated the crystal structures of several protein-crown ether co-crystals grown in the presence of 18-crown-6. We then employed biophysical methods and molecular dynamics simulations to compare these complexes with the corresponding apoproteins and with similar complexes with ring-shaped low-molecular-weight polyethylene glycols. Our studies show that crown ethers can modify protein surface behavior dramatically by stabilizing either intra- or intermolecular interactions. Consequently, we propose that crown ethers can be used to modulate a wide variety of protein surface behaviors, such as oligomerization, domain-domain interactions, stabilization in organic solvents, and crystallization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.