ArticleBMC plant biology2014
Metabolic profiling reveals altered sugar and secondary metabolism in response to UGPase overexpression in Populus.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Larix gmelinii UGPase enhances vegetative growth in transgenic poplar through an HYH-mediated positive feedback loop.Plant cell reports · 2026Article
- Integrative omics studies revealed synergistic link between sucrose metabolic isogenes and carbohydrates in poplar roots infected by Fusarium wilt.Plant molecular biology · 2024Article
- Validation of a metabolite-GWAS network forFrontiers in plant science · 2023Article
- Genome-wide alternative polyadenylation dynamics underlying plant growth retardant-induced dwarfing of pomegranate.Frontiers in plant science · 2023Article
- Elevated COPlants (Basel, Switzerland) · 2022Article
- UDP-glucose pyrophosphorylase: genome-wide identification, expression and functional analyses inPeerJ · 2022Article
- Plants Metabolome Study: Emerging Tools and Techniques.Plants (Basel, Switzerland) · 2021Review
- ARPI, β-AS, and UGE regulate glycyrrhizin biosynthesis in Glycyrrhiza uralensis hairy roots.Plant cell reports · 2021Article
- Impact of root-associated strains of three Paraburkholderia species on primary and secondary metabolism of Brassica oleracea.Scientific reports · 2021Article
- Effects of light, sucrose concentration and repetitive subculture on callus growth and medically important production inBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Early-stage sugar beet taproot development is characterized by three distinct physiological phases.Plant direct · 2020Article
- The nature of the progression of drought stress drives differential metabolomic responses in Populus deltoides.Annals of botany · 2019Article
- Response of Bioactive Metabolite and Biosynthesis Related Genes to Methyl Jasmonate Elicitation inMolecules (Basel, Switzerland) · 2019Article
- A 5-Enolpyruvylshikimate 3-Phosphate Synthase Functions as a Transcriptional Repressor inThe Plant cell · 2018Article
- Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane.PloS one · 2018Article
- The structure-activity relationship of the salicylimide derived inhibitors of UDP-sugar producing pyrophosphorylases.Plant signaling & behavior · 2018Article
- Comparative Metabolomic Analysis of the Cambium Tissue of Non-transgenic and Multi-Gene Transgenic Poplar (Frontiers in plant science · 2018Article
- A New Calmodulin-Binding Protein Expresses in the Context of Secondary Cell Wall Biosynthesis and Impacts Biomass Properties inFrontiers in plant science · 2018Article
- UDP-Sugar Producing Pyrophosphorylases: Distinct and Essential Enzymes With Overlapping Substrate Specificities, ProvidingFrontiers in plant science · 2018Review
- Overexpression of a Domain of Unknown Function 231-containing protein increases O-xylan acetylation and cellulose biosynthesis inBiotechnology for biofuels · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUDP-glucose pyrophosphorylase (UGPase) is a sugar-metabolizing enzyme (E.C. 2.7.7.9) that catalyzes a reversible reaction of UDP-glucose and pyrophosphate from glucose-1-phosphate and UTP. UDP-glucose is a key intermediate sugar that is channeled to multiple metabolic pathways. The functional role of UGPase in perennial woody plants is poorly understood.
resultsWe characterized the functional role of a UGPase gene in Populus deltoides, PdUGPase2. Overexpression of the native gene resulted in increased leaf area and leaf-to-shoot biomass ratio but decreased shoot and root growth. Metabolomic analyses showed that manipulation of PdUGPase2 results in perturbations in primary, as well as secondary metabolism, resulting in reduced sugar and starch levels and increased phenolics, such as caffeoyl and feruloyl conjugates. While cellulose and lignin levels in the cell walls were not significantly altered, the syringyl-to-guaiacyl ratio was significantly reduced.
conclusionsThese results demonstrate that PdUGPase2 plays a key role in the tightly coupled primary and secondary metabolic pathways and perturbation in its function results in pronounced effects on growth and metabolism beyond cell wall biosynthesis of Populus.
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