Trial reportPain medicine (Malden, Mass.)2014
Baseline brain activity predicts response to neuromodulatory pain treatment.
Trial report in Pain medicine (Malden, Mass.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of a Brain-Computer Interface (BCI)-Based Adaptive Sensing and Feedback for Chronic Pain Management
Effect of Hypnosis Combined to Transcranial Direct Stimulation in Cortical Activity and Pain Perception in Healthy Females
Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Effects of transcranial direct current stimulation on patient-reported outcomes in chronic low back pain: a systematic review and three-level meta-analysis.Frontiers in medicine · 2026Pooled it
- Does brain entrainment using binaural auditory beats affect pain perception in acute and chronic pain?: a systematic review.BMC complementary medicine and therapies · 2024Pooled it
- Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018Pooled it
- Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018Pooled it
- Who Benefits the Most From Different Psychological Chronic Pain Treatments? An Exploratory Analysis of Treatment Moderators.The journal of pain · 2023Trial
- Toward a Predictive Coding Account of Hypnotic Hypoalgesia: Integrating EEG Oscillations and Somatosensory Evoked Responses.Brain sciences · 2026Review
- Neural and psychophysical predictors of treatment response to transcranial direct current stimulation and mindfulness-based meditation for knee osteoarthritis pain.medRxiv : the preprint server for health sciences · 2026Article
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Increased Delta and Theta Power Density in Sickle Cell Disease Individuals with Chronic Pain Secondary to Hip Osteonecrosis: A Resting-State Eeg Study.Brain topography · 2024Article
- The Role of Electroencephalogram-Assessed Bandwidth Power in Response to Hypnotic Analgesia.Brain sciences · 2024Review
- Functional Changes in Brain Activity Using Hypnosis: A Systematic Review.Brain sciences · 2022Review
- Effects of Transcranial Direct Current Stimulation, Transcranial Pulsed Current Stimulation, and Their Combination on Brain Oscillations in Patients with Chronic Visceral Pain: A Pilot Crossover Randomized Controlled Study.Frontiers in neurology · 2017Article
- Feasibility of Non-invasive Brain Modulation for Management of Pain Related to Chemoradiotherapy in Patients with Advanced Head and Neck Cancer.Frontiers in human neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe objective of this study was to examine the associations between baseline electroencephalogram (EEG)-assessed brain oscillations and subsequent response to four neuromodulatory treatments. Based on available research, we hypothesized that baseline theta oscillations would prospectively predict response to hypnotic analgesia. Analyses involving other oscillations and the other treatments (meditation, neurofeedback, and both active and sham transcranial direct current stimulation) were viewed as exploratory, given the lack of previous research examining brain oscillations as predictors of response to these other treatments.
designRandomized controlled study of single sessions of four neuromodulatory pain treatments and a control procedure.
methodsThirty individuals with spinal cord injury and chronic pain had their EEG recorded before each session of four active treatments (hypnosis, meditation, EEG biofeedback, transcranial direct current stimulation) and a control procedure (sham transcranial direct stimulation).
resultsAs hypothesized, more presession theta power was associated with greater response to hypnotic analgesia. In exploratory analyses, we found that less baseline alpha power predicted pain reduction with meditation.
conclusionsThe findings support the idea that different patients respond to different pain treatments and that between-person treatment response differences are related to brain states as measured by EEG. The results have implications for the possibility of enhancing pain treatment response by either 1) better patient/treatment matching or 2) influencing brain activity before treatment is initiated in order to prepare patients to respond. Research is needed to replicate and confirm the findings in additional samples of individuals with chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.