ArticleHypertension (Dallas, Tex. : 1979)2015
Periodic limb movements during sleep and prevalent hypertension in the multi-ethnic study of atherosclerosis.
Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Pharmacological responsiveness of periodic limb movements in patients with restless legs syndrome: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Pooled it
- Periodic limb movements during sleep and risk of hypertension: A systematic review.Sleep medicine · 2023Pooled it
- The efficacy and tolerability of rotigotine on patients with periodic limb movement in sleep: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Correlation of hypoxic burden with blood pressure diurnal rhythm in obstructive sleep apnea.Sleep · 2026Article
- The future of periodic limb movements during sleep: beyond the periodic limb movement index.Sleep · 2026Article
- Polygenic risk scores in neurological disorders: restless legs syndrome as a translational model.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
- When the legs speak for the lungs.Sleep · 2026Article
- Comparison and Validation of Actigraphy Algorithms Using a Large Community Dataset: Algorithm Validation Study.JMIR formative research · 2025Article
- Artificial Intelligence Models for the Automation of Standard Diagnostics in Sleep Medicine-A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality.Journal of the American Heart Association · 2024Article
- Sleep related movement disorders in the elderly: a review of recent literature.Frontiers in sleep · 2024Review
- Deep Learning for Automatic Detection of Periodic Limb Movement Disorder Based on Electrocardiogram Signals.Diagnostics (Basel, Switzerland) · 2022Article
- Patients with a Higher Number of Periodic Limb Movements Have Higher Nocturnal Blood Pressure.Journal of clinical medicine · 2022Article
- Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.Annals of the American Thoracic Society · 2021Observational
- Combined unsupervised-supervised machine learning for phenotyping complex diseases with its application to obstructive sleep apnea.Scientific reports · 2021Article
- Periodic Limb Movements Syndrome in Patients With Cerebral Small Vessel Disease: Protocol for a Prospective Observational Study.Frontiers in neurology · 2021Article
- Contactless detection of periodic leg movements during sleep: A 3D video pilot study.Journal of sleep research · 2020Article
- Blood pressure monitoring in sleep: time to wake up.Blood pressure monitoring · 2020Review
- Neurological Sleep Disorders and Blood Pressure: Current Evidence.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Higher Prevalence of Hypertension among Individuals with Restless Legs Syndrome: A Meta-Analysis.Psychiatry investigation · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Periodic limb movements during sleep (PLMS) are associated with immediate increases in blood pressure. Both PLMS and hypertension have different distributions across racial/ethnic groups. We sought to determine whether PLMS is associated with hypertension among various racial/ethnic groups. A total of 1740 men and women underwent measurement of blood pressure and polysomnography with quantification of PLMS. Hypertension was defined as systolic blood pressure (SBP) ≥140, diastolic BP ≥90, or taking antihypertensive medication. For those taking antihypertensives, an estimated pretreatment SBP value was derived based on observed SBP and medication type/dose. Measures of PLMS, PLMS index, and PLMS arousal index were the main explanatory variables. Hypertension and SBP were modeled with logistic and multivariable regression adjusted for age, sex, body mass index, cardiovascular risk factors, lifestyle/habitual factors, apnea-hypopnea index, and race/ethnicity. In the overall cohort, prevalent hypertension was modestly associated with PLMS index (10 U; odds ratio, 1.05; 95% confidence interval, 1.00-1.10) and PLMS arousal index (1 U; 1.05; 1.01-1.09) after adjusting for confounders. Association in the overall cohort was influenced by large effect sizes in blacks, in whom the odds of prevalent hypertension increased by 21% (1%-45%) for 10 U PLMS index increase and 20% (2%-42%) for 1-U PLMS arousal index increase. In blacks, every 1-U PLMS arousal index increase was associated with SBP 1.01 mm Hg higher (1.01; 0.04-1.98). Associations between PLMS and blood pressure outcomes were also suggested among Chinese-Americans but not in whites or Hispanics. In a multiethnic cohort of community-dwelling men and women, prevalent hypertension and SBP are associated with PLMS frequency in blacks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.