Evidence map›Paper›PMID 25286969›Full record

ArticleEpidemiology and infection2015

Epidemiological features of pertussis resurgence based on community populations with high vaccination coverage in China.

H Huang, T Zhu, C Gao, Z Gao, Y Liu, Y Ding, J Sun, L Guo, P Liu, D Chen and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04694430 (A Integration of Respiratory Medicine and Prevention Multi-center Study to Determine the Prevalence and Influence of Pertussis on Chronic Obstructive Pulmonary Disease Exacerbation in Shenzhen by National Respiratory Diseases Clinical Medicine Research Center), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04694430 unknown statusnot on this mapstarted 2021, after this paper: background citation

A Integration of Respiratory Medicine and Prevention Multi-center Study to Determine the Prevalence and Influence of Pertussis on Chronic Obstructive Pulmonary Disease Exacerbation in Shenzhen by National Respiratory Diseases Clinical Medicine Research Center

TypeobservationalSponsorShenzhen People's HospitalRan2021 to 2021Enrolled500ConditionsCOPD Exacerbation, PertussisArmsBlood sample, Data collection, Throat swab
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Population-based active surveillance of pertussis hospitalization rates in two cities of China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Assessment of Pertussis Underreporting in Italy.Journal of clinical medicine · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

H HuangTianjin Centers for Disease Control and Prevention,Tianjin,China.
T ZhuTianjin University of Science and Technology,Tianjin,China.
C GaoTianjin CanSino Biotechnology Inc.,Tianjin,China.
Z GaoTianjin Centers for Disease Control and Prevention,Tianjin,China.
Y LiuTianjin Centers for Disease Control and Prevention,Tianjin,China.
Y DingTianjin Centers for Disease Control and Prevention,Tianjin,China.
J SunTianjin Centers for Disease Control and Prevention,Tianjin,China.
L GuoTianjin Centers for Disease Control and Prevention,Tianjin,China.
P LiuTianjin Centers for Disease Control and Prevention,Tianjin,China.
D ChenHongqiao Centers for Disease Control and Prevention,Tianjin,China.
L WangHangu Centers for Disease Control and Prevention,Tianjin,China.
S WuBeichen Centers for Disease Control and Prevention,Tianjin,China.
Y ZhangTianjin Centers for Disease Control and Prevention,Tianjin,China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Active symptom surveillance was applied to three selected communities ( 160,147 persons) in Tianjin from 2010 to 2012. We examined 1089 individuals showing pertussis-like symptoms, of which 1022 nasopharyngeal specimens were tested for pertussis by polymerase chain reaction and 802 sera for anti-pertussis toxin antibodies. Of the total cases tested, 113 were confirmed, and their demographic, clinical, and vaccination-related data were collected. The annual incidence was 23.52 cases/100,000 persons among communities, which was 16.22 times that obtained via hospital reports for the same period (P < 0.001). The actual incidence in the 15-69 years age group was most significantly underestimated by hospitals, given that it was 43.08 times that of the reported hospital rate. Among the cases aged <15 years, 84.5% were individuals who had been fully vaccinated. The misdiagnosis rate was as high as 94.69%, and only 5.31% of the confirmed pertussis cases were properly diagnosed as pertussis at their first medical visit. Pertussis incidence in China has been severely underestimated and this was in part due to a high misdiagnosis rate. Adolescents and adults have become new high-risk populations. Future work should focus on reinforcing immunization programmes, especially among adolescents and adults.

Indexed as

Epidemiological MonitoringVaccinationAdolescentAdultAgedChildChild, PreschoolChinaFemaleHumansIncidenceInfantInfant, NewbornMaleMiddle AgedPertussis ToxinPertussis ToxinCommunity populationsepidemiological featureshigh immunization coveragepertussis resurgencesymptom surveillance

Identifiers

PMID25286969
PMCPMC9507247

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.