ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Evaluation of miR-720 prognostic significance in patients with colorectal cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review.Molecular biology reports · 2021Pooled it
- Exosomal miRNA-720 as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma.The Korean journal of internal medicine · 2025Article
- Inducer microRNAs in the glioma development: a concise review of mechanisms and insights into targeted therapy.Journal of the Egyptian National Cancer Institute · 2025Review
- Diagnostic performance of serum exosomal miRNA-720 in hepatocellular carcinoma.Journal of liver cancer · 2022Article
- miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression.Human cell · 2021Article
- miR-720 Regulates Insulin Secretion by Targeting Rab35.BioMed research international · 2021Article
- Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients.Bioscience reports · 2020Observational
- Inhibition of miR-9-5p suppresses prostate cancer progress by targeting StarD13.Cellular & molecular biology letters · 2019Article
- Prognostic value of microRNAs in colorectal cancer: a meta-analysis.Cancer management and research · 2018Article
- MicroRNA-720 Regulates E-cadherin-αE-catenin Complex and Promotes Renal Cell Carcinoma.Molecular cancer therapeutics · 2017Article
- MiR-200 suppresses metastases of colorectal cancer through ZEB1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.International journal of molecular sciences · 2016Article
- MicroRNA-720 suppresses M2 macrophage polarization by targeting GATA3.Bioscience reports · 2016Article
- miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.Breast cancer research : BCR · 2016Article
- MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice.BMC cancer · 2016Article
- Ginsenoside Rh2 alleviates tumor-associated depression in a mouse model of colorectal carcinoma.American journal of translational research · 2016Article
- MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer.Molecular cancer · 2015Article
- Non-coding landscapes of colorectal cancer.World journal of gastroenterology · 2015Review
- MicroRNA-720 promotes in vitro cell migration by targeting Rab35 expression in cervical cancer cells.Cell & bioscience · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant expression of miR-720 had been reported in several cancers. However, the expression level and prognostic value of miR-720 in colorectal cancer (CRC) had not been addressed. In our study, we detected the expression level of miR-720 in 96 CRC tissues to evaluate its clinicopathological characteristics in colorectal cancer. Kaplan-Meier survival curve was performed to evaluate the prognostic role of miR-720 in patients with CRC. Furthermore, in vitro, we transfected the miR-720 mimics or inhibitors into the corresponding CRC cell lines and evaluated the effects on the abilities of cell growth, colony formation, migration, wound healing, and invasion in CRC cells. Our data showed that miR-720 level was significantly upregulated in CRC tissues than that in corresponding normal-appearing tissues (NATs) (p < 0.05), and high miR-720 correlated with the tumor size (p = 0.014), tumor-node-metastasis (TNM) stage (p = 0.040), lymphatic metastasis (p = 0.008), and distant metastasis (p = 0.016), which led to a poorer 5-year overall survival rate in CRC patients (p < 0.05). Our experiments in vitro also confirmed that miR-720 could promote the cell growth (p < 0.05), abilities of colony formation (p < 0.05), wound healing (p < 0.05), migration (p < 0.05), and invasion of CRC cells (p < 0.05). We identified StarD13 gene as a putative target of miR-720 in colorectal cancer by bioinformatics analysis, and subsequent dual luciferase activity and Western blot assay further certified that miR-720 might specifically target the StarD13 3'-untranslated region (UTR) at the 795 region (p < 0.05). miR-720 might act as a promoting factor in the development of CRC and could be a prognostic indicator in the prognosis of CRC. Downregulation of miR-720 might be considered to be a potentially important molecular treatment strategy for early stage CRC patients.
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