Evidence map›Paper›PMID 25286305›Full record

ReviewThe international journal of biochemistry & cell biology2014

Structural analysis of glyceraldehyde-3-phosphate dehydrogenase functional diversity.

Michael A Sirover

Open access · greenAbstract readReview
In one paragraph

Review in The international journal of biochemistry & cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Evaluation of Salivary GAPDH as a Predictor Biomarker for Periodontitis.International journal of molecular sciences · 2025
    Article
  6. Proteomic Profile ofInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. TgKDAC4: A Unique Deacetylase ofMicroorganisms · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael A SiroverDepartment of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, United States. Electronic address: msirover@temple.edu.
Temple University · US

Funding

New Mechanism of Carcinogen and Antioxidant DetectionR03CA119285 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI SIROVER, MICHAEL ALAN · 2005 to 2006
$148k
NCI NIH HHS CA 119285NCI NIH HHS R03 CA119285
6 · The paper itself

Abstract

Multifunctional proteins provide a new mechanism to expand exponentially cell information and capability beyond that indicated by conventional gene analyses. As such, examination of their structure-function relationships provides a means to define the mechanisms through which cells accomplish critical yet disparate activities required for cell viability and survival. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) may be considered the quintessential multidimensional protein which exhibits a variety of functions unrelated to its classical role in energy production. This review discusses new insights into the structure-function mechanisms through which defined GAPDH amino acid domains are utilized for its diverse activities, the importance of its post-translational modification, and, intriguingly, the logic inherent in the presence or the absence of specific signaling domains.

Indexed as

Amino Acid SequenceAnimalsGlyceraldehyde-3-Phosphate DehydrogenasesHumansMolecular Sequence DataGlyceraldehyde-3-Phosphate DehydrogenasesAmino acid domainsGlyceraldehyde-3-phosphate dehydrogenasemRNA stabilityMultifunctional proteinPost-translational modification

Identifiers

PMID25286305
PMCPMC4268148
OpenAlexW1966542721

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.