ArticleJAMA pediatrics2014
Bisphenol a exposure and the development of wheeze and lung function in children through age 5 years.
Article in JAMA pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00129324 (Neurobehavioral Effects of Prevalent Neurotoxicants in Children), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurobehavioral Effects of Prevalent Neurotoxicants in Children: A Cohort Study of the Cincinnati Center for Children's Environmental Health
Who cites it
33 citing papers in PubMed, 82 citations in OpenAlex.
- Microplastics and nanoplastics in human health: a comprehensive review of exposure pathways, cellular mechanisms, and toxicological implications.Archives of toxicology · 2026Review
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies.Journal of exposure science & environmental epidemiology · 2025Article
- Early-life exposure to a mixture of phenols and respiratory health in preschool children.The European respiratory journal · 2025Article
- Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Discovery of common molecular signatures and drug repurposing for COVID-19/Asthma comorbidity: ACE2 and multi-partite networks.Cell cycle (Georgetown, Tex.) · 2024Article
- Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma.Current environmental health reports · 2023Review
- Relationship between prenatal and postnatal exposure to BPA and its analogues (BPS, BPF) and allergic diseases.International journal of occupational medicine and environmental health · 2023Review
- Prenatal bisphenol A and S exposure and atopic disease phenotypes at age 6.Environmental research · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Longitudinal effects of prenatal exposure to plastic-derived chemicals and their metabolites on asthma and lung function from childhood into adulthood.Respirology (Carlton, Vic.) · 2023Article
- Effects of Oral Exposure to Low-Dose Bisphenol S on Allergic Asthma in Mice.International journal of molecular sciences · 2022Article
- Does fetal leptin and adiponectin influence children's lung function and risk of wheeze?Journal of developmental origins of health and disease · 2021Article
- Prenatal and postnatal exposure to Bisphenol A and Asthma: a systemic review and meta-analysis.Journal of thoracic disease · 2021Article
- Gestational Pesticide Exposure and Child Respiratory Health.International journal of environmental research and public health · 2020Article
- Prenatal phthalate, paraben, and phenol exposure and childhood allergic and respiratory outcomes: Evaluating exposure to chemical mixtures.The Science of the total environment · 2020Article
- Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile.BMJ open · 2020Article
- Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes.Environmental research · 2020Article
- Bisphenol A Activates an Innate Viral Immune Response Pathway.Journal of proteome research · 2020Article
- An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
importanceBisphenol A (BPA), a prevalent endocrine-disrupting chemical, has been associated with wheezing in children, but few studies have examined its effect on lung function or wheeze in older children.
objectivesTo test whether BPA exposure is associated with lung function, with wheeze, and with pattern of wheeze in children during their first 5 years. DESIGN, SETTING, AND
participantsA birth cohort study, enrolled during early pregnancy in the greater Cincinnati, Ohio, area among 398 mother-infant dyads. We collected maternal urine samples during pregnancy (at 16 and 26 weeks) and child urine samples annually to assess gestational and child BPA exposure. MAIN OUTCOMES AND MEASURES: We assessed parent-reported wheeze every 6 months for 5 years and measured child forced expiratory volume in the first second of expiration (FEV1) at age 4 and 5 years. We evaluated associations of BPA exposure with respiratory outcomes, including FEV1, child wheeze, and wheeze phenotype.
resultsUrinary BPA concentrations and FEV1 data were available for 208 children and urinary BPA concentrations and parent-reported wheeze data were available for 360 children. The mean maternal urinary BPA concentration ranged from 0.53 to 293.55 µg/g of creatinine. In multivariable analysis, every 10-fold increase in the mean maternal urinary BPA concentration was associated with a 14.2% (95% CI, -24.5% to -3.9%) decrease in the percentage predicted FEV1 at 4 years, but no association was found at 5 years. In multivariable analysis, every 10-fold increase in the mean maternal urinary BPA concentration was marginally associated with a 54.8% increase in the odds of wheezing (adjusted odds ratio, 1.55; 95% CI, 0.91-2.63). While the mean maternal urinary BPA concentration was not associated with wheeze phenotype, a 10-fold increase in the 16-week maternal urinary BPA concentration was associated with a 4.27-fold increase in the odds of persistent wheeze (adjusted odds ratio, 4.27; 95% CI, 1.37-13.30). Child urinary BPA concentrations were not associated with FEV1 or wheeze. CONCLUSIONS AND RELEVANCE: These results provide evidence suggesting that prenatal but not postnatal exposure to BPA is associated with diminished lung function and the development of persistent wheeze in children.
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