ArticleThe journal of physical chemistry. B2015
Interactions of lipids and detergents with a viral ion channel protein: molecular dynamics simulation studies.
Article in The journal of physical chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Blocking bacterial appendage attachment to wastewater treatment membranes using anti-adhesins.Chemosphere · 2023Article
- The Impact of Lipid Digestion on the Dynamic and Structural Properties of Micelles.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
- How Do Branched Detergents Stabilize GPCRs in Micelles?Biochemistry · 2020Article
- Physico-chemical characteristics of evaporating respiratory fluid droplets.Journal of the Royal Society, Interface · 2018Article
- How Do Short Chain Nonionic Detergents Destabilize G-Protein-Coupled Receptors?Journal of the American Chemical Society · 2016Article
- Functional characterization of p7 viroporin from hepatitis C virus produced in a cell-free expression system.Protein expression and purification · 2016Article
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Authors and funding
2 authors.
Funding
Abstract
Structural studies of membrane proteins have highlighted the likely influence of membrane mimetic environments (i.e., lipid bilayers versus detergent micelles) on the conformation and dynamics of small α-helical membrane proteins. We have used molecular dynamics simulations to compare the conformational dynamics of BM2 (a small α-helical protein from the membrane of influenza B) in a model phospholipid bilayer environment with its behavior in protein-detergent complexes with either the zwitterionic detergent dihexanoylphosphatidylcholine (DHPC) or the nonionic detergent dodecylmaltoside (DDM). We find that DDM more closely resembles the lipid bilayer in terms of its interaction with the protein, while the short-tailed DHPC molecule forms "nonphysiological" interactions with the protein termini. We find that the intrinsic micelle properties of each detergent are conserved upon formation of the protein-detergent complex. This implies that simulations of detergent micelles may be used to help select optimal conditions for experimental studies of membrane proteins.
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