Evidence map›Paper›PMID 25286028›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2014

Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer.

Zhongwu Li, Yanling Wang, Chunping Yuan, Yumin Zhu, Jing Qiu, Wei Zhang, Bing Qi, Heming Wu, Jinhai Ye, Hongbing Jiang and 2 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  11. Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Article
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  13. Curcumin Derivative C086 Combined with Cisplatin Inhibits Proliferation of Osteosarcoma Cells.Medical science monitor : international medical journal of experimental and clinical research · 2020
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  17. Knockdown of long non-coding RNA ANRIL inhibits tumorigenesis in human gastric cancer cells via microRNA-99a-mediated down-regulation of BMI1.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Zhongwu Li1] Head Neck Cancer Center, Institute of Stomatology, Nanjing Medical University, Jiangsu, China [2] Jiangsu Key Laboratory of Oral Disease, Nanjing, China.
Yanling Wang1] Head Neck Cancer Center, Institute of Stomatology, Nanjing Medical University, Jiangsu, China [2] Jiangsu Key Laboratory of Oral Disease, Nanjing, China.
Chunping YuanHead Neck Cancer Center, Institute of Stomatology, Nanjing Medical University, Jiangsu, China.
Yumin ZhuJiangsu Key Laboratory of Oral Disease, Nanjing, China.
Jing QiuJiangsu Key Laboratory of Oral Disease, Nanjing, China.
Wei ZhangDepartment of Oral Pathology, Nanjing, China.
Bing QiDepartment of Oral Pathology, Nanjing, China.
Heming WuDepartment of Oral and Maxillofacial Surgery Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China.
Jinhai YeDepartment of Oral and Maxillofacial Surgery Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China.
Hongbing JiangDepartment of Oral and Maxillofacial Surgery Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China.
Jianrong YangDepartment of Oral and Maxillofacial Surgery Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China.
Jie Cheng1] Head Neck Cancer Center, Institute of Stomatology, Nanjing Medical University, Jiangsu, China [2] Department of Oral and Maxillofacial Surgery Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The polycomb complex protein Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) mediates epigenetic transcriptional silencing by modifying chromatin structure and is critical for stem cell homeostasis and tumorigenesis. Bmi1 is frequently overexpressed in human malignancies and therefore has key diagnostic and prognostic significance, and holds potential as a therapeutic target. Here we sought to characterize the expression patterns and oncogenic roles of Bmi1 in tongue squamous cell carcinoma and to determine the anticancer effects of histone deacetylase inhibitors (HDACis) via Bmi1 inhibition against tongue cancer. Our data revealed that Bmi1 was aberrantly overexpressed in a significant portion of tongue cancers. Elevated Bmi1 is associated with cervical node metastasis, Ki-67 abundance and reduced overall survival, and also serves as an independent prognostic factor for patient outcomes. Short-hairpin RNA-mediated Bmi1 knockdown inhibited cell proliferation and migration, induced cell apoptosis and senescence, reduced colony formation and CD44(+)CD133(+) sub-population as well as enhanced cisplatin chemosensitivity, presumably by modulation of p16, p14 and E-cadherin. Moreover, HDACi chemicals Trichostatin A (TSA) and sodium butyrate (NaB) potently inhibited Bmi1 and triggered similar phenotypic changes reminiscent of Bmi1 silencing, although TSA treatment seemed paradoxically to induce some epithelial-mesenchymal transition-like changes in tongue cancer cells. Importantly, NaB-induced antitumor effects were partially attenuated by enforced Bmi1 overexpression in vitro. Genetic Bmi1 silencing and pharmacological inhibition of Bmi1 by NaB treatment significantly impaired tumor growth in a tongue cancer xenograft model. Taken together, our results indicate that Bmi1 serves as a key driver and biomarker with multiple oncogenic functions underlying tongue tumorigenesis. Selected appropriate HDACi compounds like NaB may represent novel therapeutic agents against tongue cancer.

Indexed as

AdultAgedAnimalsApoptosisCarcinoma, Squamous CellCell Line, TumorCisplatinEpithelial-Mesenchymal TransitionFemaleHistone Deacetylase InhibitorsHumansKi-67 AntigenMaleMiceMiddle AgedPolycomb Repressive Complex 1BMI1 protein, humanCisplatinHistone Deacetylase InhibitorsKi-67 AntigenPolycomb Repressive Complex 1RNA, Small Interfering

Identifiers

PMID25286028
OpenAlexW1991392180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.