ArticleJournal of the American Chemical Society2014
High-throughput 3D cell invasion chip enables accurate cancer metastatic assays.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Exploring bone-tumor interactions through 3DJournal of bone oncology · 2025Review
- Simple and automatic monitoring of cancer cell invasion into an epithelial monolayer using label-free holographic microscopy.Scientific reports · 2022Article
- Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review.Bio-design and manufacturing · 2021Review
- Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting.Nature biomedical engineering · 2021Article
- Preoperative evaluation of microvascular invasion with circulating tumour DNA in operable hepatocellular carcinoma.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration.Small (Weinheim an der Bergstrasse, Germany) · 2019Review
- Colorimetric and Raman spectroscopic array for detection of hydrogen peroxide and glucose based on etching the silver shell of Au@Ag core-shell nanoparticles.Mikrochimica acta · 2019Article
- Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations.Molecules (Basel, Switzerland) · 2019Review
- Single-cell mRNA cytometry via sequence-specific nanoparticle clustering and trapping.Nature chemistry · 2018Article
- Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes.Macromolecular bioscience · 2017Article
- Enrichment and single-cell analysis of circulating tumor cells.Chemical science · 2017Article
- Nanomaterial-based Microfluidic Chips for the Capture and Detection of Circulating Tumor Cells.Nanotheranostics · 2017Review
- Microfluidic models for adoptive cell-mediated cancer immunotherapies.Drug discovery today · 2016Review
- Recent Progress of Microfluidics in Translational Applications.Advanced healthcare materials · 2016Review
- Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering.Sensors (Basel, Switzerland) · 2015Review
- High-Throughput, Label-Free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity.Angewandte Chemie (International ed. in English) · 2015Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Chemotaxis is the phenomenon by which the migration and invasion of cells is directed in response to an extracellular chemical gradient. Chemotaxis of tumor cells and tumor-associated inflammatory and stromal cells is mediated by chemokines, chemokine receptors, growth factors, and growth factor receptors. Current techniques used to study chemotactic driven cell invasion and metastasis utilize two-dimensional migration assays involving imaging and analyzing tumor cells on glass slides or plastic surfaces, which requires large numbers of cells and often lacks real-time monitoring of vertical cell movement and systematically controlled chemotactic gradients, leading to contradictory results compared to those from clinical investigations and animal models. We addressed such challenges by developing a high-throughput microdevice with 4000 ultraminiaturized wells to monitor real-time, three-dimensional cell invasion over a wide range of cell densities and also screen drugs that inhibit cell invasion and potentially prevent metastatic malignancy. Additionally, this microdevice generates opposing gradients for two types of cells on the same chip, which builds a controlled system with sequentially changing components to study environmental effects from basal and immune cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.