Evidence map›Paper›PMID 25285876›Full record

ReviewJournal of psychiatry & neuroscience : JPN2015

Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology.

Linda Booij, Richard E Tremblay, Moshe Szyf, Chawki Benkelfat

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of psychiatry & neuroscience : JPN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 124 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.Journal of psychopharmacology (Oxford, England) · 2025
    Review
  6. Article
  7. Article
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  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Development of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  16. Article
  17. Exploring the Contribution of Proximal Family Risk Factors onInternational journal of environmental research and public health · 2021
    Article
  18. Article
  19. Modeling endophenotypes of suicidal behavior in animals.Neuroscience and biobehavioral reviews · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Linda BooijSainte-Justine Hospital Research Center & University of Montréal, Montréal, Que.; Department of Psychology and Psychiatry, Queen's University, Kingston, Ont.; Department of Psychiatry, McGill University, Montréal, Que.; Department of Psychiatry, University of Montréal, Montréal, Que.
Richard E TremblaySainte-Justine Hospital Research Center & University of Montréal, Montréal, Que.; Departments of Psychology and Pediatrics, University of Montréal, Montréal, Que.; School of Public Health and Population Sciences, University College Dublin, Dublin, Ireland.
Moshe SzyfDepartment of Pharmacology and Therapeutics, McGill University, Montréal, Que., Canada.
Chawki BenkelfatDepartment of Psychiatry, McGill University, Montréal, Que.
Queen's University · CAUniversité de Montréal · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundDespite more than 60 years of research in the role of serotonin (5-HT) in psychopathology, many questions still remain. From a developmental perspective, studies have provided more insight into how 5-HT dysfunctions acquired in utero or early in life may modulate brain development. This paper discusses the relevance of the developmental role of 5-HT for the understanding of psychopathology. We review developmental milestones of the 5-HT system, how genetic and environmental 5-HT disturbances could affect brain development and the potential role of DNA methylation in 5-HT genes for brain development.

methodsStudies were identified using common databases (e.g., PubMed, Google Scholar) and reference lists.

resultsDespite the widely supported view that the 5-HT system matures in early life, different 5-HT receptors, proteins and enzymes have different developmental patterns, and development is brain region-specific. A disruption in 5-HT homeostasis during development may lead to structural and functional changes in brain circuits that modulate emotional stress responses, including subcortical limbic and (pre)frontal areas. This may result in a predisposition to psychopathology. DNA methylation might be one of the underlying physiologic mechanisms. LIMITATIONS: There is a need for prospective studies. The impact of stressors during adolescence on the 5-HT system is understudied. Questions regarding efficacy of drugs acting on 5-HT still remain.

conclusionA multidisciplinary and longitudinal approach in designing studies on the role of 5-HT in psychopathology might help to bring us closer to the understanding of the role of 5-HT in psychopathology.

Indexed as

Gene-Environment InteractionAnimalsBrainEnvironmentEpigenesis, GeneticGenetic Predisposition to DiseaseHumansMental DisordersSerotoninSerotonin

Identifiers

PMID25285876
PMCPMC4275332
OpenAlexW1992525659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.