ArticleJournal of the American Chemical Society2014
Diatom mimics: directing the formation of biosilica nanoparticles by controlled folding of lysine-leucine peptides.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 58 citations in OpenAlex.
- Bioengineered silicon nanoparticles in agroecosystems: molecular mechanisms, stress tolerance, and environmental implications.Frontiers in plant science · 2026Review
- Nanoengineered Silica-Based Biomaterials for Regenerative Medicine.International journal of molecular sciences · 2024Review
- Mesoporous silica nanoparticles with chiral pattern topological structure function as "antiskid tires" on the intestinal mucosa to facilitate oral drugs delivery.Asian journal of pharmaceutical sciences · 2023Article
- Intrinsically Disordered Osteopontin Fragment Orders During Interfacial Calcium Oxalate Mineralization.Angewandte Chemie (International ed. in English) · 2021Article
- Bioinspired Scaffolding by Supramolecular Amines Allows the Formation of One- and Two-Dimensional Silica Superstructures.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Article
- Otoferlin C2F Domain-Induced Changes in Membrane Structure Observed by Sum Frequency Generation.Biophysical journal · 2019Article
- Peptide-Controlled Assembly of Macroscopic Calcium Oxalate Nanosheets.The journal of physical chemistry letters · 2019Article
- A REDOR ssNMR Investigation of the Role of an N-Terminus Lysine in R5 Silica Recognition.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Solid state deuterium NMR study of LKα14 peptide aggregation in biosilica.Biointerphases · 2017Article
- Ubiquitin immobilized on mesoporous MCM41 silica surfaces - Analysis by solid-state NMR with biophysical and surface characterization.Biointerphases · 2017Article
- Biogenic and Synthetic Peptides with Oppositely Charged Amino Acids as Binding Sites for Mineralization.Materials (Basel, Switzerland) · 2017Article
- Tipping the Scale from Disorder to Alpha-helix: Folding of Amphiphilic Peptides in the Presence of Macroscopic and Molecular Interfaces.PLoS computational biology · 2015Article
- Peptide-equipped tobacco mosaic virus templates for selective and controllable biomineral deposition.Beilstein journal of nanotechnology · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Silaffins, long chain polyamines, and other biomolecules found in diatoms are involved in the assembly of a large number of silica nanostructures under mild, ambient conditions. Nanofabrication researchers have sought to mimic the diatom's biosilica production capabilities by engineering proteins to resemble aspects of naturally occurring biomolecules. Such mimics can produce monodisperse biosilica nanospheres, but in vitro production of the variety of intricate biosilica nanostructures that compose the diatom frustule is not yet possible. In this study we demonstrate how LK peptides, composed solely of lysine (K) and leucine (L) amino acids arranged with varying hydrophobic periodicities, initiate the formation of different biosilica nanostructures in vitro. When L and K residues are arranged with a periodicity of 3.5 the α-helical form of the LK peptide produces monodisperse biosilica nanospheres. However, when the LK periodicity is changed to 3.0, corresponding to a 310 helix, the morphology of the nanoparticles changes to elongated rod-like structures. β-strand LK peptides with a periodicity of 2.0 induce wire-like silica morphologies. This study illustrates how the morphology of biosilica can be changed simply by varying the periodicity of polar and nonpolar amino acids.
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