ArticleBehavioral neuroscience2014
The contribution of medial prefrontal cortical regions to conditioned inhibition.
Article in Behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The effects of prelimbic inhibition on time-based intervention and impulsive choice.Behavioural brain research · 2027Article
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- Infralimbic Projections to the Substantia Innominata-Ventral Pallidum Constrain Defensive Behavior during Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Infralimbic cortex plays a similar role in the punishment and extinction of instrumental behavior.Neurobiology of learning and memory · 2024Article
- Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons.Neuron · 2022Article
- Serotonin 1B receptor effects on response inhibition are independent of inhibitory learning.Neurobiology of learning and memory · 2022Article
- A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity.Frontiers in behavioral neuroscience · 2022Review
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
- Salient safety conditioning improves novel discrimination learning.Behavioural brain research · 2021Article
- Neural correlates of safety learning.Behavioural brain research · 2021Article
- The role of the ventromedial prefrontal cortex and context in regulating fear learning and extinction.Psychology & neuroscience · 2020Article
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- Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation.Neuroscience and biobehavioral reviews · 2020Review
- Loss of Hierarchical Control by Occasion Setters Following Lesions of the Prelimbic and Infralimbic Medial Prefrontal Cortex in Rats.Brain sciences · 2019Article
- Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus.Journal of psychopharmacology (Oxford, England) · 2017Article
- Posterior insular cortex is necessary for conditioned inhibition of fear.Neurobiology of learning and memory · 2016Article
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- Review
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2 authors.
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Abstract
Few studies have considered the process by which individuals learn to omit a response, which is an essential aspect of adaptive behavior. Several lines of evidence indicate that two regions of the medial prefrontal cortex have disparate roles in behavioral flexibility. In particular, the prelimbic cortex (PL) is thought to facilitate the generation of a strategy to inhibit a prepotent response, whereas the infralimbic cortex (IL) appears to be more important for maintaining extensively trained inhibitory behaviors. The present experiments were designed to elucidate the contributions of PL and IL to the acquisition and maintenance of Pavlovian conditioned inhibition. In Experiment 1, damage to PL before training in a compound feature negative discrimination task impaired inhibitory learning. By comparison, lesions of IL had little effect. In Experiment 2, lesions of PL or IL occurred after overtraining, and damage to IL significantly impaired subsequent performance in the task, suggesting that this region is involved in the continued expression of Pavlovian conditioned inhibition after thorough training. PL may also be involved in maintaining inhibition, as evidenced by a marginally significant lesion-induced performance deficit. These data support the notion that PL and IL have distinguishable roles in modulating inhibition, while contributing important information about the specific role for PL in acquisition of an inhibitory response and IL in performance.
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