ArticleeLife2014
The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation.Current biology : CB · 2022Article
- The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.PLoS genetics · 2022Article
- Regulation of Neural Stem Cell Competency and Commitment during Indirect Neurogenesis.International journal of molecular sciences · 2021Review
- Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors.PLoS genetics · 2021Article
- Article
- Krüppel-like factor/specificity protein evolution in the Spiralia and the implications for cephalopod visual system novelties.Proceedings. Biological sciences · 2020Article
- Dynamics of activating and repressive histone modifications inDevelopment (Cambridge, England) · 2019Article
- Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs.Neural plasticity · 2019Article
- The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation.Aging and disease · 2017Review
- An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division.Developmental cell · 2017Article
- The Ets protein Pointed prevents both premature differentiation and dedifferentiation of Drosophila intermediate neural progenitors.Development (Cambridge, England) · 2016Article
- Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff.Development (Cambridge, England) · 2016Article
- Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.Development (Cambridge, England) · 2016Article
- Proliferation control in neural stem and progenitor cells.Nature reviews. Neuroscience · 2015Review
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Intermediate neural progenitor cells (INPs) need to avoid differentiation and cell cycle exit while maintaining restricted developmental potential, but mechanisms preventing differentiation and cell cycle exit of INPs are not well understood. In this study, we report that the Drosophila homolog of mammalian Sp8 transcription factor Buttonhead (Btd) prevents premature differentiation and cell cycle exit of INPs in Drosophila larval type II neuroblast (NB) lineages. We show that the loss of Btd leads to elimination of mature INPs due to premature differentiation of INPs into terminally dividing ganglion mother cells. We provide evidence to demonstrate that Btd prevents the premature differentiation by suppressing the expression of the homeodomain protein Prospero in immature INPs. We further show that Btd functions cooperatively with the Ets transcription factor Pointed P1 to promote the generation of INPs. Thus, our work reveals a critical mechanism that prevents premature differentiation and cell cycle exit of Drosophila INPs.
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