ArticlePloS one2014
FEV1 is a better predictor of mortality than FVC: the PLATINO cohort study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta‑analysis of factors predicting postoperative lung function after lung cancer resection.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Pooled it
- A cohort study of forced vital capacity, airway obstruction, and survival in the multinational Burden of Obstructive Lung Disease study.International journal of epidemiology · 2026Article
- Lung function predicts mortality in people with serious mental illness: A 6-year follow-up study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients.International journal of molecular sciences · 2025Article
- A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease.Scientific reports · 2025Observational
- Circulating Biomarkers, Fraction of Exhaled Nitric Oxide, and Lung Function in Patients With Human Immunodeficiency Virus and Tuberculosis.The Journal of infectious diseases · 2024Article
- Article
- Trajectories of Spirometric Patterns, Obstructive and PRISm, in a Population-Based Cohort in Latin America.International journal of chronic obstructive pulmonary disease · 2023Article
- Glucocorticoid Alleviates Mechanical Stress-Induced Airway Inflammation and Remodeling in COPD via Transient Receptor Potential Canonical 1 Channel.International journal of chronic obstructive pulmonary disease · 2023Article
- FVC, but not FEVScientific reports · 2022Article
- Predicting COPD Progression in Current and Former Smokers Using a Joint Model for Forced Expiratory Volume in 1 Second and Forced Expiratory Volume in 1 Second to Forced Vital Capacity Ratio.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022Article
- All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts.Scientific reports · 2022Article
- Lung Function After Coronavirus Disease 2019: Some Answers, More Questions.The Journal of infectious diseases · 2022Article
- Household air pollution and COPD: cause and effect or confounding by other aspects of poverty?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Review
- Reduced FEVFrontiers in medicine · 2022Article
- Dynamic Metabolic Risk Profiling of World Trade Center Lung Disease: A Longitudinal Cohort Study.American journal of respiratory and critical care medicine · 2021Article
- Dietary phenotype and advanced glycation end-products predict WTC-obstructive airways disease: a longitudinal observational study.Respiratory research · 2021Observational
- Pulmonary restriction predicts long-term pulmonary impairment in people with HIV and tuberculosis.BMC pulmonary medicine · 2021Article
- Muscle mass and function are related to respiratory function in chronic obstructive pulmonary disease.Medical journal of the Islamic Republic of Iran · 2021Article
- Association of lung function with overall mortality is independent of inflammatory, cardiac, and functional biomarkers in older adults: the ActiFE-study.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort. MATERIALS/PATIENTS AND
methodsPopulation based cohorts were followed in Montevideo, Santiago and Sao Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression was used for analyses. Sensitivity, specificity, positive and negative predictive values, receiver operator characteristics curves and Youden's index were calculated.
resultsMain causes of death were cardiovascular, respiratory and cancer. Baseline COPD was associated with overall mortality (HR = 1.43 for FEV1/FVC<LLN; 2.01 for GOLD 2-4; 1.46 for GOLD 1-4; 1.50 for FEV1/FEV6 <LLN). For cardiovascular mortality, significant associations were found with GOLD 2-4 (HR = 2.68) and with GOLD 1-4 (HR = 1.78) for both genders together (not among women). Low FEV1 was risk for overall and respiratory mortality (both genders combined). FVC was not associated with overall mortality. For most COPD criteria sensitivity was low and specificity high. The area under the curve for FEV1 was greater than for FVC for overall and cardiovascular mortality. ANSWER TO THE QUESTION: COPD and low FEV1 are important predictors for overall and cardiovascular mortality in Latin America.
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