ReviewFrontiers in neuroendocrinology2015
Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity.
Review in Frontiers in neuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- [Hormonal influence on hearing].HNO · 2021Pooled it
- Article
- Perinatal activation of ERJournal of neurophysiology · 2021Article
- Sodium Fluoride In Vitro Treatment Affects the Expression of Gonadotropin and Steroid Hormone Receptors in Chicken Embryonic Gonads.Animals : an open access journal from MDPI · 2021Article
- Brain-Derived Neurotrophic Factor Has a Transsynaptic Trophic Effect on Neural Activity in an Adult Forebrain Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Inefficient neural system stabilization: a theory of spontaneous resolutions and recurrent relapses in psychosisJournal of psychiatry & neuroscience : JPN · 2019Review
- Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system.Developmental neurobiology · 2019Article
- Sexually Dimorphic Patterns of Cell Proliferation in the Brain Are Linked to Seasonal Life-History Transitions in Red-Sided Garter Snakes.Frontiers in neuroscience · 2018Article
- Dissociable Effects on Birdsong of Androgen Signaling in Cortex-Like Brain Regions of Canaries.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Activation of the peripheral immune system regulates neuronal aromatase in the adult zebra finch brain.Scientific reports · 2017Article
- Central Administration of Indomethacin Mitigates the Injury-Induced Upregulation of Aromatase Expression and Estradiol Content in the Zebra Finch Brain.Endocrinology · 2017Article
- Sex and age differences in brain-derived neurotrophic factor and vimentin in the zebra finch song system: Relationships to newly generated cells.The Journal of comparative neurology · 2016Article
- Determinants and significance of corticosterone regulation in the songbird brain.General and comparative endocrinology · 2016Review
- Activity Dependency and Aging in the Regulation of Adult Neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The avian song control system provides an excellent model for studying transsynaptic trophic effects of steroid sex hormones. Seasonal changes in systemic testosterone (T) and its metabolites regulate plasticity of this system. Steroids interact with the neurotrophin brain-derived neurotrophic factor (BDNF) to influence cellular processes of plasticity in nucleus HVC of adult birds, including the addition of newborn neurons. This interaction may also occur transsynpatically; T increases the synthesis of BDNF in HVC, and BDNF protein is then released by HVC neurons on to postsynaptic cells in nucleus RA where it has trophic effects on activity and morphology. Androgen action on RA neurons increases their activity and this has a retrograde trophic effect on the addition of new neurons to HVC. The functional linkage of sex steroids to BDNF may be of adaptive value in regulating the trophic effects of the neurotrophin and coordinating circuit function in reproductively relevant contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.