Evidence map›Paper›PMID 25285241›Full record

ArticleHereditary genetics : current research2013

Triple Negative Breast Cancer - An Overview.

Kartik Aysola, Akshata Desai, Crystal Welch, Jingyao Xu, Yunlong Qin, Vaishali Reddy, Roland Matthews, Charlotte Owens, Joel Okoli, Derrick J Beech and 3 more

Abstract read
In one paragraph

Article in Hereditary genetics : current research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Review
  4. Article
  5. [Research square · 2026
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kartik AysolaCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Akshata DesaiDepartment of Internal Medicine, University of Buffalo, Erie County Medical Center, 462 Grider St, Buffalo NY 14215, USA.
Crystal WelchCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Jingyao XuCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Yunlong QinCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Vaishali ReddyCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Roland MatthewsCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Charlotte OwensCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Joel OkoliDepartment of Surgery, Morehouse School of Medicine, Grady Health System, Atlanta, GA 30303, USA.
Derrick J BeechDepartment of Surgery, Morehouse School of Medicine, Grady Health System, Atlanta, GA 30303, USA.
Chandrika J PiyathilakeWallace Tumour Institute 420 D, 1824 6th Avenue South, University of Alabama at Birmingham, Birmingham AL 35294, USA.
Shyam P ReddyCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.
Veena N RaoCancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.

Funding

Morehouse School of Medicine Center of Excellence Research Endowment ProgramS21MD000101 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2001 to 2015
$74.3M
TRANSCRIPTION FACTORS AND PROSTATE CANCERG12RR003034 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI ZHAO, XUEYING · 1986 to 2011
$32.4M
Research Training & Career Development ProgramU54CA118638 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI Brian M. Rivers · 2005 to 2026
$22.7M
WARCEFP20RR011104 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI MENG, YUAN-XIANG · 1995 to 2009
$14.5M
NCI NIH HHS U54 CA118638NCRR NIH HHS G12 RR003034NCRR NIH HHS P20 RR011104NIMHD NIH HHS S21 MD000101
6 · The paper itself

Abstract

Triple Negative Breast Cancer (TNBC) is a heterogeneous disease that based on immunohistochemistry (IHC) is estrogen receptor (ER) negative, progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative. TNBC is typically observed in young AA women and Hispanic women who carry a mutation in the BRCA1 gene. TNBC is characterized by a distinct molecular profile, aggressive nature and lack of targeted therapies. The purpose of this article is to review the current and future novel signalling pathways as therapeutic approaches to TNBC. Recent Identification of a new BRCA1 trafficking pathway holds promise in the future for the development of targeted therapies for TNBC.

Indexed as

BCL-2BRCA1CISPLATINEGFRHedgehogNOTCHPARPTNBCUBC9WNT/B-CATENIN

Identifiers

PMID25285241
PMCPMC4181680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.