Evidence map›Paper›PMID 25285199›Full record

ReviewInterface focus2014

Biological mechanisms underlying the role of physical fitness in health and resilience.

Marni N Silverman, Patricia A Deuster

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Interface focus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05348044 (Feasibility Study to Increase Resilience Through an At-home Virtual Exercise Training), which is not on this map. Cited by 216 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 6 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05348044 nacompletednot on this mapstarted 2022, after this paper: background citation

Feasibility Study to Increase Resilience Through an At-home Virtual Exercise Training (Res-ET) Intervention Using Inspiratory Muscle Strength Training (IMST)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2023Enrolled19ConditionsResilience, StrokeArmsRes-ET intervention
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 6 syntheses or guidelines pooled it, 381 citations in OpenAlex.

  1. Pooled it
  2. Recreational physical activity and health-related quality of life among breast cancer survivors: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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  18. Heart rate response to cannabis in active older adults.European journal of applied physiology · 2026
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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Marni N SilvermanConsortium for Health and Military Performance, Department of Military and Emergency Medicine , Uniformed Services University of the Health Sciences , Bethesda, MD 20814 , USA.
Patricia A DeusterConsortium for Health and Military Performance, Department of Military and Emergency Medicine , Uniformed Services University of the Health Sciences , Bethesda, MD 20814 , USA.
Google (United States) · USUniformed Services University of the Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical fitness, achieved through regular exercise and/or spontaneous physical activity, confers resilience by inducing positive psychological and physiological benefits, blunting stress reactivity, protecting against potentially adverse behavioural and metabolic consequences of stressful events and preventing many chronic diseases. In this review, we discuss the biological mechanisms underlying the beneficial effects of physical fitness on mental and physical health. Physical fitness appears to buffer against stress-related disease owing to its blunting/optimizing effects on hormonal stress responsive systems, such as the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. This blunting appears to contribute to reduced emotional, physiological and metabolic reactivity as well as increased positive mood and well-being. Another mechanism whereby regular exercise and/or physical fitness may confer resilience is through minimizing excessive inflammation. Chronic psychological stress, physical inactivity and abdominal adiposity have been associated with persistent, systemic, low-grade inflammation and exert adverse effects on mental and physical health. The anti-inflammatory effects of regular exercise/activity can promote behavioural and metabolic resilience, and protect against various chronic diseases associated with systemic inflammation. Moreover, exercise may benefit the brain by enhancing growth factor expression and neural plasticity, thereby contributing to improved mood and cognition. In summary, the mechanisms whereby physical fitness promotes increased resilience and well-being and positive psychological and physical health are diverse and complex.

Indexed as

autonomic nervous systemexercisehypothalamic–pituitary–adrenal (HPA) axisinflammationneuroplasticitystress

Identifiers

PMID25285199
PMCPMC4142018
OpenAlexW2158629827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.