Evidence map›Paper›PMID 25285164›Full record

ArticleTheranostics2014

Photostimulable near-infrared persistent luminescent nanoprobes for ultrasensitive and longitudinal deep-tissue bio-imaging.

Yen-Jun Chuang, Zipeng Zhen, Fan Zhang, Feng Liu, Jyoti P Mishra, Wei Tang, Hongmin Chen, Xinglu Huang, Lianchun Wang, Xiaoyuan Chen and 2 more

Abstract read
In one paragraph

Article in Theranostics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Nanoscintillator-Based X-Ray-Induced Photodynamic Therapy.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. HNature communications · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. LiGaMaterials horizons · 2017
    Article
  20. New function of the YbLight, science & applications · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yen-Jun Chuang1. College of Engineering, University of Georgia, Athens, GA 30602, USA;
Zipeng Zhen2. Department of Chemistry, University of Georgia, Athens, GA 30602, USA; ; 3. Bio-Imaging Research Center, University of Georgia, Athens, GA 30602, USA;
Fan Zhang4. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20852, USA;
Feng Liu1. College of Engineering, University of Georgia, Athens, GA 30602, USA; ; 5. Department of Physics and Astronomy, University of Georgia, Athens, GA 30602, USA;
Jyoti P Mishra6. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA; ; 7. Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Wei Tang2. Department of Chemistry, University of Georgia, Athens, GA 30602, USA; ; 3. Bio-Imaging Research Center, University of Georgia, Athens, GA 30602, USA;
Hongmin Chen2. Department of Chemistry, University of Georgia, Athens, GA 30602, USA; ; 3. Bio-Imaging Research Center, University of Georgia, Athens, GA 30602, USA;
Xinglu Huang4. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20852, USA;
Lianchun Wang6. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA; ; 7. Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Xiaoyuan Chen4. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20852, USA;
Jin Xie2. Department of Chemistry, University of Georgia, Athens, GA 30602, USA; ; 3. Bio-Imaging Research Center, University of Georgia, Athens, GA 30602, USA;
Zhengwei Pan1. College of Engineering, University of Georgia, Athens, GA 30602, USA; ; 5. Department of Physics and Astronomy, University of Georgia, Athens, GA 30602, USA;

Funding

TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY W. · 2012 to 2019
$14.5M
Robo4 and heparan sulfate proteoglycan in angiogenesisR01HL093339 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LIANCHUN · 2009 to 2018
$3.4M
Nanoplatform-based combinational therapy against breast cancer R00CA153772 · NCI · UNIVERSITY OF GEORGIA · PI XIE, JIN · 2011 to 2013
$710k
NCI NIH HHS 5R00CA153772NCI NIH HHS R00 CA153772NHLBI NIH HHS R01 HL093339NHLBI NIH HHS R01HL093339NIGMS NIH HHS GM103390NIGMS NIH HHS P41 GM103390
6 · The paper itself

Abstract

In vivo fluorescence imaging suffers from suboptimal signal-to-noise ratio and shallow detection depth, which is caused by the strong tissue autofluorescence under constant external excitation and the scattering and absorption of short-wavelength light in tissues. Here we address these limitations by using a novel type of optical nanoprobes, photostimulable LiGa5O8:Cr(3+) near-infrared (NIR) persistent luminescence nanoparticles, which, with very-long-lasting NIR persistent luminescence and unique photo-stimulated persistent luminescence (PSPL) capability, allow optical imaging to be performed in an excitation-free and hence, autofluorescence-free manner. LiGa5O8:Cr(3+) nanoparticles pre-charged by ultraviolet light can be repeatedly (>20 times) stimulated in vivo, even in deep tissues, by short-illumination (~15 seconds) with a white light-emitting-diode flashlight, giving rise to multiple NIR PSPL that expands the tracking window from several hours to more than 10 days. Our studies reveal promising potential of these nanoprobes in cell tracking and tumor targeting, exhibiting exceptional sensitivity and penetration that far exceed those afforded by conventional fluorescence imaging.

Indexed as

Luminescent MeasurementsAnimalsBrainCell LineCell SurvivalChromium CompoundsDiagnostic ImagingGallic AcidLithium CompoundsMacrophagesMiceNanoparticlesOptical ImagingUltraviolet RaysChromium CompoundsGallic AcidLithium Compoundsin vivo imaging.LiGa5O8:Cr3+ nanoparticlesnear-infraredpersistent luminescencephotostimulated persistent luminescence

Identifiers

PMID25285164
PMCPMC4173761

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.