ArticleTheranostics2014
Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model.
Article in Theranostics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Fatty acid synthase-derived lipid stores support breast cancer metastasis.Cancer & metabolism · 2025Article
- Epigenetic regulation of HOXA2 expression affects tumor progression and predicts breast cancer patient survival.Cell death and differentiation · 2025Article
- Crosstalk between lipid metabolism and EMT: emerging mechanisms and cancer therapy.Molecular and cellular biochemistry · 2025Article
- Clinical application of photoacoustic imaging for cervical precursor lesion detection.Journal of medical ultrasonics (2001) · 2025Article
- Oxygenation heterogeneity facilitates spatiotemporal flow pattern visualization inside human blood vessels using photoacoustic computed tomography.Biomedical optics express · 2024Article
- Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors.Journal of biomedical optics · 2023Article
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
- Enhancement of in vivo cardiac photoacoustic signal specificity using spatiotemporal singular value decomposition.Journal of biomedical optics · 2021Article
- Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging.Advances in experimental medicine and biology · 2021Article
- CD63Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Oxygen-Enhanced Optoacoustic Tomography Reveals the Effectiveness of Targeting Heme and Oxidative Phosphorylation at Normalizing Tumor Vascular Oxygenation.Cancer research · 2020Article
- Evaluation of ductal carcinoma in situ grade via triple-modal molecular imaging of B7-H3 expression.NPJ breast cancer · 2020Article
- EMT Factors and Metabolic Pathways in Cancer.Frontiers in oncology · 2020Review
- Multidomain computational modeling of photoacoustic imaging: verification, validation, and image quality prediction.Journal of biomedical optics · 2019Review
- Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy.International journal of molecular sciences · 2019Review
- Photoacoustic imaging as a tool to probe the tumour microenvironment.Disease models & mechanisms · 2019Review
- Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7-H3 Expression in Breast Cancer.Bioconjugate chemistry · 2019Article
- Photoacoustic oximetry imaging performance evaluation using dynamic blood flow phantoms with tunable oxygen saturation.Biomedical optics express · 2019Article
- State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics.Contrast media & molecular imaging · 2019Review
- Intraoperative Resection Guidance with Photoacoustic and Fluorescence Molecular Imaging Using an Anti-B7-H3 Antibody-Indocyanine Green Dual Contrast Agent.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the potential of multiparametric spectroscopic photoacoustic imaging using oxygen saturation, total hemoglobin, and lipid content to differentiate among four different breast histologies (normal, hyperplasia, ductal carcinoma in situ (DCIS), and invasive breast carcinoma) in a transgenic mouse model of breast cancer development. MATERIALS AND
methodsAnimal studies were approved by the Institutional Administrative Panel on Laboratory Animal Care. Mammary glands (n=251) of a transgenic mouse model of breast cancer development (FVB/N-Tg(MMTV-PyMT)634Mul) were imaged using B-mode ultrasound and spectroscopic photoacoustic imaging, analyzed for oxygen saturation, total hemoglobin, and lipid content, and processed for histological analysis. Statistical analysis was performed using one-way ANOVA, two-sample t-tests, logistic regression, and ROC analysis.
resultsEighty-two normal, 12 hyperplastic, 96 DCIS, and 61 invasive breast carcinoma mammary glands were analyzed. Based on spectroscopic photoacoustic imaging, the oxygen saturation of hyperplasia (50.6%), DCIS (43.0%), and invasive carcinoma (46.2%) significantly increased compared to normal glands (35.5%, P <0.0001), while both total hemoglobin (P<0.01), and lipid content (P<0.0008) significantly decreased with advancing histology. In differentiating normal and hyperplasia from DCIS and invasive breast carcinoma, multiparametric imaging of oxygen saturation, lipid content, and raw photoacoustic signal at 750 nm provided an AUC value of 0.770.
conclusionMultiparametric spectroscopic photoacoustic imaging is feasible and allows detection of differences in concentration of tissue chromophores among different histologies in a transgenic mouse model of breast cancer development.
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