Evidence map›Paper›PMID 25285157›Full record

ArticleNeurodegenerative disease management2013

Should we disclose amyloid imaging results to cognitively normal individuals?

Joshua D Grill, David K Johnson, Jeffrey M Burns

Abstract read
In one paragraph

Article in Neurodegenerative disease management, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
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  11. Article
  12. Added value of amyloid PET in individualized risk predictions for MCI patients.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. American journal of nuclear medicine and molecular imaging · 2018
    Review
  19. Review
  20. Safety of disclosing amyloid status in cognitively normal older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joshua D GrillMary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, UCLA David Geffen School of Medicine.
David K JohnsonUniversity of Kansas Alzheimer's Disease Center.
Jeffrey M BurnsUniversity of Kansas Alzheimer's Disease Center.
University of Kansas · USFoundation for Psychocultural Research · US

Funding

UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BREDESEN, DALE E. · 1999 to 2014
$25.9M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SWERDLOW, RUSSELL H. · 2011 to 2020
$16.6M
Heartland Unit for Neuroscience TrialsU10NS077356 · NINDS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2011 to 2017
$2.1M
Aerobic Fitness in Slowing the Progression of Alzheimer's DiseaseR01AG033673 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BURNS, JEFFREY MURRAY · 2010 to 2014
$1.7M
Dose-Response Study of Exercise in Older AdultsR01AG034614 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BURNS, JEFFREY MURRAY · 2009 to 2011
$772k
NIA NIH HHS P30 AG035982NIA NIH HHS P50 AG016570NIA NIH HHS R01 AG033673NIA NIH HHS R01 AG034614NINDS NIH HHS U10 NS077356
6 · The paper itself

Abstract

Demonstration of brain accumulation of fibrillar amyloid beta protein via positron emission tomography (PET) with amyloid specific ligands may support the diagnosis of Alzheimer's disease (AD). There is increasing recognition of the potential use of amyloid imaging to detect

Indexed as

Alzheimer's diseaseamyloid PETdisclosureethics

Identifiers

PMID25285157
PMCPMC4184474
OpenAlexW2061522475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.