Evidence map›Paper›PMID 25285117›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2014

Community-associated methicillin-resistant Staphylococcus aureus necrotizing pneumonia without evidence of antecedent viral upper respiratory infection.

Cristina Moran Toro, Jack Janvier, Kunyan Zhang, Kevin Fonseca, Dan Gregson, Deirdre Church, Kevin Laupland, Harvey Rabin, Sameer Elsayed, John Conly

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. A Study on the Epidemiological-Molecular Role ofAntibiotics (Basel, Switzerland) · 2023
    Article
  2. Article
  3. Review
  4. Airborne Staphylococcus aureus in different environments-a review.Environmental science and pollution research international · 2019
    Review
  5. Article
  6. Community-associated MRSA: superbug at our doorstep.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Cristina Moran ToroDepartartments of Medicine, University of Calgary;
Jack JanvierDepartartments of Medicine, University of Calgary;
Kunyan ZhangDepartartments of Medicine, University of Calgary;
Kevin FonsecaMicrobiology, Immunology and Infectious Diseases, University of Calgary; ; Provincial Laboratory of Alberta, Alberta Health Services;
Dan GregsonDepartartments of Medicine, University of Calgary; ; Pathology and Laboratory Medicine, University of Calgary; ; The Calvin, Phoebe and Joan Synder Institute for Chronic Diseases, Alberta Health Services - Calgary Zone and University of Calgary; ; Calgary Laboratory Services;
Deirdre ChurchDepartartments of Medicine, University of Calgary; ; Pathology and Laboratory Medicine, University of Calgary; ; The Calvin, Phoebe and Joan Synder Institute for Chronic Diseases, Alberta Health Services - Calgary Zone and University of Calgary; ; Calgary Laboratory Services;
Kevin LauplandDepartartments of Medicine, University of Calgary; ; Pathology and Laboratory Medicine, University of Calgary; ; The Calvin, Phoebe and Joan Synder Institute for Chronic Diseases, Alberta Health Services - Calgary Zone and University of Calgary; ; Calgary Laboratory Services; ; Departments of Critical Care Medicine, University of Calgary; ; Community Health Sciences, University of Calgary;
Harvey RabinDepartartments of Medicine, University of Calgary; ; Microbiology, Immunology and Infectious Diseases, University of Calgary; ; The Calvin, Phoebe and Joan Synder Institute for Chronic Diseases, Alberta Health Services - Calgary Zone and University of Calgary;
Sameer ElsayedDepartments of Medicine, University of Western Ontario, London, Ontario ; Microbiology and Infectious Diseases, University of Western Ontario, London, Ontario.
John ConlyDepartartments of Medicine, University of Calgary;
University of Calgary · CACalgary Laboratory Services · CAAlberta Health Services · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUSA300 community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) strains causing necrotizing pneumonia have been reported in association with antecedent viral upper respiratory tract infections (URI).

methodsA case series of necrotizing pneumonia presenting as a primary or coprimary infection, secondary to CA-MRSA without evidence of antecedent viral URI, is presented. Cases were identified through the infectious diseases consultation service records. Clinical and radiographic data were collected by chart review and electronic records. MRSA strains were isolated from sputum, bronchoalveolar lavage, pleural fluid or blood cultures and confirmed using standard laboratory procedures. MRSA strains were characterized by susceptibility testing, pulsed-field gel electrophoresis, spa typing, agr typing and multilocus sequence typing. Testing for respiratory viruses was performed by appropriate serological testing of banked sera, or nucleic acid testing of nasopharyngeal or bronchoalveloar lavage specimens.

resultsTen patients who presented or copresented with CA necrotizing pneumonia secondary to CA-MRSA from April 2004 to October 2011 were identified. The median length of stay was 22.5 days. Mortality was 20.0%. Classical risk factors for CA-MRSA were identified in seven of 10 (70.0%) cases. Chest tube placement occurred in seven of 10 patients with empyema. None of the patients had historical evidence of antecedent URI. In eight of 10 patients, serological or nucleic acid testing testing revealed no evidence of acute viral coinfection. Eight strains were CMRSA-10 (USA300). The remaining two strains were a USA300 genetically related strain and a USA1100 strain.

conclusionPneumonia secondary to CA-MRSA can occur in the absence of an antecedent URI. Infections due to CA-MRSA are associated with significant morbidity and mortality. Clinicians need to have an awareness of this clinical entity, particularly in patients who are in risk groups that predispose to exposure to this bacterium.

Indexed as

Community-associated methicillin-resistantNecrosisPneumoniaStaphylococcus aureusViral infection

Identifiers

PMID25285117
PMCPMC4173983
OpenAlexW2218610481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.