ArticleInfection and immunity1989
Comparison of T-cell responses in self-limiting versus progressive visceral Leishmania donovani infections in golden hamsters.
Article in Infection and immunity, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
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- Th1-biased immunomodulation and therapeutic potential of Artemisia annua in murine visceral leishmaniasis.PLoS neglected tropical diseases · 2015Article
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- Immunoadjuvant chemotherapy of visceral leishmaniasis in hamsters using amphotericin B-encapsulated nanoemulsion template-based chitosan nanocapsules.Antimicrobial agents and chemotherapy · 2013Article
- Leishmania donovani infection induces anemia in hamsters by differentially altering erythropoiesis in bone marrow and spleen.PloS one · 2013Article
- Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?International journal for parasitology. Drugs and drug resistance · 2012Review
- Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis.Seminars in immunopathology · 2012Review
- The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice.EMBO molecular medicine · 2012Article
- Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression.PLoS pathogens · 2012Article
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- Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation.Parasites & vectors · 2011Article
- Combination therapy with paromomycin-associated stearylamine-bearing liposomes cures experimental visceral leishmaniasis through Th1-biased immunomodulation.Antimicrobial agents and chemotherapy · 2011Article
- Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system.PLoS neglected tropical diseases · 2011Article
- Visceral leishmaniasis: experimental models for drug discovery.The Indian journal of medical research · 2011Review
- Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits immunity against visceral leishmaniasis.European journal of immunology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Leishmania donovani infection in golden hamsters was studied as a model for human kala-azar. After intradermal inoculation of L. donovani amastigotes, hamsters developed positive skin reactions (delayed-type hypersensitivity [DTH]) to parasite antigens and lymphoid cells from these hamsters proliferated to parasite antigens in vitro and transferred DTH reactivity to normal recipients. In contrast, hamsters infected by the intracardial route developed progressive visceral infections and failed to respond to skin test antigens. Spleen cells, lymph node cells, and peripheral blood lymphocytes (PBLs) from these hamsters were unresponsive to parasite antigens in vitro, and spleen cells failed to transfer DTH to normal recipients. Spleen cells, but not PBLs, displayed depressed responses to T-cell mitogens and also suppressed the proliferative response of cells from hamsters inoculated intradermally. Removal of adherent cells restored the capacity of spleen cells, but not PBLs, to respond to parasite antigens. The nonadherent population of these spleen cells also transferred DTH to normal recipients. The adherent suppressor cells, which have the characteristics of macrophages, appear to be localized to the spleen and are apparently not responsible for the failure of peripheral lymphoid cells to respond to antigen. These studies suggest that hamsters with visceral infections develop a population of antigen-reactive cells and that in the absence of suppression these cells may express functional activities, including the capacity to elicit DTH responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.