ArticleInternational journal of nanomedicine2014
Use of electrical impedance spectroscopy to detect malignant and potentially malignant oral lesions.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders-Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- The clinical application of electrical impedance technology in the detection of malignant neoplasms: a systematic review.Journal of translational medicine · 2020Pooled it
- Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett's Carcinoma.Journal of gastrointestinal cancer · 2022Trial
- Ultrasensitive detection of oral cancer biomarkers CD63 and CD44 in exosomes using janus particles: a rotational diffusometry-based assay.The Saudi dental journal · 2026Article
- In Vivo Classification of Oral Lesions Using Electrical Impedance Spectroscopy.IEEE transactions on bio-medical engineering · 2026Article
- Comparison of Complex Open Domain Electrical Impedance Tomography Methods.IEEE transactions on bio-medical engineering · 2025Article
- Deep learning-based electrical impedance spectroscopy analysis for malignant and potentially malignant oral disorder detection.Scientific reports · 2025Article
- Electrical impedance-based tissue classification for bladder tumor differentiation.Scientific reports · 2025Article
- Application of Electrical Impedance Tomography in Diagnosis of Cancer.Advanced biomedical research · 2025Review
- Assessment of a Bioimpedance-Based Method for the Diagnosis of Oral Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- The Diagnostic Potential of Non-Invasive Tools for Oral Cancer and Precancer: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- The Use of Virtual Tissue Constructs That Include Morphological Variability to Assess the Potential of Electrical Impedance Spectroscopy to Differentiate between Thyroid and Parathyroid Tissues during Surgery.Sensors (Basel, Switzerland) · 2024Article
- Multiscale Model Development for Electrical Properties of Thyroid and Parathyroid Tissues.IEEE open journal of engineering in medicine and biology · 2024Article
- The acceptability of cervical electrical impedance spectroscopy within a multi-modal preterm birth screening package: a mixed methods study.BMC pregnancy and childbirth · 2022Article
- Impact of Age and Sex on Electrical Impedance Values in Healthy Oral Mucosa.Bioengineering (Basel, Switzerland) · 2022Article
- Computational Modelling for Electrical Impedance Spectroscopy-Based Diagnosis of Oral Potential Malignant Disorders (OPMD).Sensors (Basel, Switzerland) · 2022Article
- Unmet Needs and Perspectives in Oral Cancer Prevention.Cancers · 2022Review
- Bioelectric, tissue, and molecular characteristics of the gastric mucosa at different times of ischemia.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Cervical Cancer Prognosis and Diagnosis Using Electrical Impedance Spectroscopy.Journal of electrical bioimpedance · 2021Article
- Skin Electrical Resistance as a Diagnostic and Therapeutic Biomarker of Breast Cancer Measuring Lymphatic Regions.IEEE access : practical innovations, open solutions · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The electrical properties of tissues depend on their architecture and cellular composition. We have previously shown that changes in electrical impedance can be used to differentiate between different degrees of cervical dysplasia and cancer of the cervix. In this proof-of-concept study, we aimed to determine whether electrical impedance spectroscopy (EIS) could distinguish between normal oral mucosa; benign, potentially malignant lesions (PML); and oral cancer. EIS data were collected from oral cancer (n=10), PML (n=27), and benign (n=10) lesions. EIS from lesions was compared with the EIS reading from the normal mucosa on the contralateral side of the mouth or with reference spectra from mucosal sites of control subjects (n=51). Healthy controls displayed significant differences in the EIS obtained from different oral sites. In addition, there were significant differences in the EIS of cancer and high-risk PML versus low-risk PML and controls. There was no significant difference between benign lesions and normal controls. Study subjects also deemed the EIS procedure considerably less painful and more convenient than the scalpel biopsy procedure. EIS shows promise at distinguishing among malignant, PML, and normal oral mucosa and has the potential to be developed into a clinical diagnostic tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.