ArticleInternational journal of nanomedicine2014
Oxygen supersaturated fluid using fine micro/nanobubbles.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 67 citations in OpenAlex.
- Effect of Lipid Composition and Stirring Dynamics on Oxygen Microbubble Stability and Oxygen Release.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies.Nanomaterials (Basel, Switzerland) · 2023Review
- Review
- The effect of preparation time and aeration rate on the properties of bulk micro-nanobubble water using hydrodynamic cavitation.Ultrasonics sonochemistry · 2022Article
- Nanobubbles activate anaerobic growth and metabolism of Pseudomonas aeruginosa.Scientific reports · 2021Article
- Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives.RSC advances · 2021Review
- Free radical degradation in aqueous solution by blowing hydrogen and carbon dioxide nanobubbles.Scientific reports · 2021Article
- Cerebrospinal fluid oxygen optimisation for rescue of metabolically challenged in vitro cortical brain tissue.IBRO reports · 2020Article
- Effective delivery of mycophenolic acid by oxygen nanobubbles for modulating immunosuppression.Theranostics · 2020Article
- Article
- Simple method to make a supersaturated oxygen fluid.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Article
- Oxygen-Carrying Micro/Nanobubbles: Composition, Synthesis Techniques and Potential Prospects in Photo-Triggered Theranostics.Molecules (Basel, Switzerland) · 2018Review
- Data on a simple method for producing a solution that contains a high partial pressure of oxygen and a low partial pressure of carbon dioxide.Data in brief · 2018Article
- Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery.International wound journal · 2018Review
- Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.American journal of obstetrics and gynecology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.