The Autodigestion Hypothesis in Shock and Multi-Organ Failure: Degrading Protease Activity.

Geert W Schmid-Schönbein, Alex Penn, Erik Kistler

Abstract read

In one paragraph

Article in Boletim da Sociedade Portuguesa de Hemorreologia e Microcirculacao, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Challenge to the Intestinal Mucosa During Sepsis.Frontiers in immunology · 2019
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Geert W Schmid-SchönbeinMicrocirculation Laboratory, Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093 - 0412.

Alex PennMicrocirculation Laboratory, Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093 - 0412.

Erik KistlerMicrocirculation Laboratory, Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093 - 0412.

Funding

Digestive Enzymes and Microvascular Inflammation in ShockR01GM085072 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHMID-SCHOENBEIN, GEERT W. · 2009 to 2017

$2.2M

Microvascular Injury and Pancreatic Enzyme ProductsR01HL067825 · NHLBI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SCHMID-SCHOENBEIN, GEERT W. · 2001 to 2005

$1.5M

NHLBI NIH HHS R01 HL067825NIGMS NIH HHS R01 GM085072

6 · The paper itself

Abstract

Shock and multi-organ failure have one of the highest levels of inflammatory markers, morbidities and mortality. The underlying mechanisms are currently unknown and no effective intervention exists. We present evidence for a previously untested mechanism due to

Indexed as

chymotrypsindigestive pancreaselastasehemorrhagic shockinflammationintestinal mucosaIntestinesepsistrypsin

Identifiers

PMID25284955

PMCPMC4180238

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.