ArticleAncient science of life2013
Evaluation of a Unani polyherbal formulation (Tiryaqe wabai) as an immunostimulator in elderly persons.
Article in Ancient science of life, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 24 citations in OpenAlex.
- Tiryāq in traditional Persian medicine: a survey of antidotal plants and their modern pharmacological potential.Frontiers in pharmacology · 2025Review
- Analytical review ofJournal of herbal medicine · 2023Review
- Overview of Covid-19; its prevention and management in the light of Unani medicine.The Science of the total environment · 2020Review
- Methods of health promotion and disease prevention in Unani medicine.Journal of education and health promotion · 2020Review
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsElderly subjects have a dysregulation of immune response mainly due to the changes in cell - mediated immunity. Due to their weakened immune response, the elderly are at increased risk of infection and related complications. In Unani medicine Tiryaq wabai was used for the prevention of epidemic diseases during outbreaks, but it has not been explored scientifically so far. The study was aimed to evaluate the immune-stimulating effect of Tiryaq wabai in elderly. MATERIALS AND
methodsA randomized placebo controlled trial was conducted at National Institute of Unani Medicine Hospital, Bangalore. Thirty immunocompromised elderly persons were selected on the basis of clinical examination considering parameters like history of recurrent infection, unexplained weight loss, persistent diarrhea etc. They were randomly assigned, 20 in test and 10 in the control group. Tiryaq wabai was given to test group 500 mg orally thrice in a week for 45 days. Placebo was given orally to the control group at a dose of 500 mg thrice in a week for 45 days. Response was assessed by total leucocyte count (TLC), lymphocyte percentage, absolute lymphocyte count (ALC), CD4 and CD8 count. The results were analyzed statistically using Graph Pad InStat 3.
resultsThe test drug showed statistically significant increase in TLC (P < 0.001), lymphocyte percentage (P < 0.001),ALC (P < 0.001), CD4 count (P < 0.001) in comparison to control group, but increase in CD8 count was not statistically significant. No major adverse effect was observed throughout the study.
conclusionThe findings outlined above indicate immune- stimulating activity of Tiryaq wabai and supports its use in conditions where immunostimulation is required and thus is suggestive of therapeutic usefulness.
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