Evidence map›Paper›PMID 25284739›Full record

Trial reportJournal of manipulative and physiological therapeutics

Immediate changes after manual therapy in resting-state functional connectivity as measured by functional magnetic resonance imaging in participants with induced low back pain.

Charles W Gay, Michael E Robinson, Steven Z George, William M Perlstein, Mark D Bishop

4 registry-linked trialsOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of manipulative and physiological therapeutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03531541 nacompletednot on this map

Transcutaneous Electrical Nerve Stimulation and Cervical Joint Manipulation on Pressure Pain Threshold

TypeinterventionalSponsorUniversidade Federal de Sao CarlosRan2018 to 2019Enrolled144ConditionsPainArmsApplication of TENS, CJM, Placebo TENS, Placebo CJM
NCT03541538 nacompletednot on this map

Hypoalgesic Effects of Specific vs Non-specific Cervical Manipulation in Healthy Subjects

TypeinterventionalSponsorUniversidade Federal de Sao CarlosRan2018 to 2018Enrolled21ConditionsPainArmsGlobal manipulation, Especific manipulation
NCT04347551 nacompletednot on this map

Motor Performance of Asymptomatic and Chronic Neck Pain Participants Pre- and Post-spinal Manipulation Using an Eye and Head Movement Fitts' Task

TypeinterventionalSponsorUniversity of ManitobaRan2021 to 2021Enrolled40ConditionsChronic Neck PainArmsHigh velocity/low amplitude cervical spine manipulation
NCT04935775 nacompletednot on this map

The Effect of Touch on Pain and Anxiety During the Bone Marrow Biopsy Procedure

TypeinterventionalSponsorDartmouth-Hitchcock Medical CenterRan2021 to 2022Enrolled46ConditionsPain, Acute, AnxietyArmsUntrained Touch
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charles W GayPostdoctoral Research Fellow, Rehabilitation Science, College of Public and Health and Health Professions, University of Florida, Gainesville, Fla. Electronic address: chaz.gay@ufl.edu.
Michael E RobinsonProfessor, Department of Clinical and Health Psychology, College of Public and Health and Health Professions, University of Florida, Gainesville, FL.
Steven Z GeorgeAssociate Professor and Assistant Department Chair, Department of Physical Therapy, College of Public and Health and Health Professions, University of Florida, Gainesville, FL.
William M PerlsteinAssociate Professor, Department of Clinical and Health Psychology, College of Public and Health and Health Professions, University of Florida, Gainesville, FL; Research Health Scientist, VA RR&D Brain Rehabilitation Research Center of Excellence (151A), Malcom Randall Veterans Administration Medical Center, Gainesville, FL.
Mark D BishopAssociate Professor, Department of Physical Therapy, College of Public and Health and Health Professions, University of Florida, Gainesville, FL.
University of Florida · US

Funding

Advanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M
Central Mechanisms of Body Based Intervention for Musculoskeletal Low Back PainR01AT006334 · NCCIH · UNIVERSITY OF FLORIDA · PI BISHOP, MARK D. · 2011 to 2015
$1.6M
CENTRAL MECHANISMS OF MANIPULATIVE AND BODY-BASED INTERVENTIONS: TRAINING PROGRAMF32AT007729 · NCCIH · UNIVERSITY OF FLORIDA · PI PENZA, CHARLES W · 2013 to 2015
$200k
NCCIH NIH HHS F32 AT007729NCCIH NIH HHS F32 AT007729-01A1NCCIH NIH HHS R01 AT006334NCCIH NIH HHS R01AT006334
6 · The paper itself

Abstract

objectiveThe purposes of this study were to use functional magnetic resonance imaging to investigate the immediate changes in functional connectivity (FC) between brain regions that process and modulate the pain experience after 3 different types of manual therapies (MT) and to identify reductions in experimentally induced myalgia and changes in local and remote pressure pain sensitivity.

methodsTwenty-four participants (17 men; mean age ± SD, 21.6 ± 4.2 years) who completed an exercise-injury protocol to induce low back pain were randomized into 3 groups: chiropractic spinal manipulation (n = 6), spinal mobilization (n = 8), or therapeutic touch (n = 10). The primary outcome was the immediate change in FC as measured on functional magnetic resonance imaging between the following brain regions: somatosensory cortex, secondary somatosensory cortex, thalamus, anterior and posterior cingulate cortices, anterior and poster insula, and periaqueductal gray. Secondary outcomes were immediate changes in pain intensity, measured with a 101-point numeric rating scale, and pain sensitivity, measured with a handheld dynamometer. Repeated-measures analysis of variance models and correlation analyses were conducted to examine treatment effects and the relationship between within-person changes across outcome measures.

resultsChanges in FC were found between several brain regions that were common to all 3 MT interventions. Treatment-dependent changes in FC were also observed between several brain regions. Improvement was seen in pain intensity after all interventions (P < .05) with no difference between groups (P > .05). There were no observed changes in pain sensitivity, or an association between primary and secondary outcome measures.

conclusionThese results suggest that MTs (chiropractic spinal manipulation, spinal mobilization, and therapeutic touch) have an immediate effect on the FC between brain regions involved in processing and modulating the pain experience. This suggests that neurophysiologic changes after MT may be an underlying mechanism of pain relief.

Indexed as

AdultBrain MappingFemaleHumansLow Back PainMagnetic Resonance ImagingMaleManipulation, ChiropracticManipulation, OsteopathicManipulation, SpinalModels, TheoreticalPain MeasurementPain PerceptionPain ThresholdRisk FactorsSingle-Blind MethodChiropracticMagnetic Resonance ImagingMusculoskeletal ManipulationsNeurophysiology Brain

Identifiers

PMID25284739
PMCPMC4248017
OpenAlexW2044441627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.