Evidence map›Paper›PMID 25284181›Full record

ArticleFaraday discussions2014

Lanthanide nano-drums: a new class of molecular nanoparticles for potential biomedical applications.

Richard A Jones, Annie J Gnanam, Jonathan F Arambula, Jessica N Jones, Jagannath Swaminathan, Xiaoping Yang, Desmond Schipper, Justin W Hall, Lauren J DePue, Yakhya Dieye and 6 more

Abstract read
In one paragraph

Article in Faraday discussions, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. DNA-interacting lanthanide complexes with a DOTA-derived dipyrido[3,2-Dalton transactions (Cambridge, England : 2003) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Richard A JonesDepartment of Chemistry, The University of Texas at Austin, 105 E. 24th St. Stop A5300, Austin, Texas 78712, USA. rajones@cm.utexas.edu.
Annie J Gnanam
Jonathan F Arambula
Jessica N Jones
Jagannath Swaminathan
Xiaoping Yang
Desmond Schipper
Justin W Hall
Lauren J DePue
Yakhya Dieye
Jamuna Vadivelu
Don J Chandler
Edward M Marcotte
Jonathan L Sessler
Lauren I R Ehrlich
Katherine A Brown

Funding

The contribution of GPCRs to thymocyte medullary entry and central toleranceR01AI104870 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI Lauren Ilyse Richie EHRLICH · 2014 to 2026
$7.6M
Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
Next-Generation Proteomics: Massively Parallel Single-Molecule Protein IdentificaDP1GM106408 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MARCOTTE, EDWARD M · 2012 to 2016
$3.8M
Novel Molecular Recognition Reagents for Detection of Pathogenic BurkholderiaU01AI078008 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI BROWN, KATHERINE ANNE · 2008 to 2010
$1.8M
NCI NIH HHS CA68682NCI NIH HHS R01 CA068682NIAID NIH HHS 1U01AI078008-3NIAID NIH HHS R01 AI104870NIAID NIH HHS U01 AI078008NIGMS NIH HHS DP1 GM106408
6 · The paper itself

Abstract

We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide "nano-drums" are homogeneous 4d-4f clusters approximately 25 to 30 Å in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.

Indexed as

Antineoplastic AgentsBiomedical ResearchCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansLanthanoid Series ElementsMetal NanoparticlesModels, MolecularMolecular StructureNanomedicineOrganometallic CompoundsStructure-Activity RelationshipAntineoplastic AgentsLanthanoid Series ElementsOrganometallic Compounds

Identifiers

PMID25284181
PMCPMC4407017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.