Evidence map›Paper›PMID 25283972›Full record

ArticleACS nano2014

Hybrid nanotrimers for dual T1 and T2-weighted magnetic resonance imaging.

Kai Cheng, Meng Yang, Ruiping Zhang, Chunxia Qin, Xinhui Su, Zhen Cheng

Abstract read
In one paragraph

Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Multifunctional Magnetic Resonance Imaging Probes.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  2. Review
  3. Article
  4. Rational Design of Magnetic Nanoparticles as TMolecules (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. GdProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Review
  11. Article
  12. Fe/Mn Multilayer Nanowires as High-Performance TMaterials (Basel, Switzerland) · 2021
    Article
  13. Diagnostic and Therapeutic Nanomedicine.Advances in experimental medicine and biology · 2021
    Article
  14. Review
  15. Article
  16. Review
  17. TACS applied bio materials · 2018
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kai ChengMolecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University , 1201 Welch Road, Lucas P095, Stanford, California 94305-5484, United States.
Meng Yang
Ruiping Zhang
Chunxia Qin
Xinhui Su
Zhen Cheng

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Stanford Nanocharacterization LaboratoryU54CA119367 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2006 to 2010
$19.8M
NCI NIH HHS CCNE-TR U54 CA119367NCI NIH HHS P30 CA124435NCI NIH HHS U54 CA119367
6 · The paper itself

Abstract

Development of multifunctional nanoparticle-based probes for dual T1- and T2-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T1 and T2- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Their potential as dual contrast agents for T1 and T2-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements.

Indexed as

NanostructuresContrast MediaMagnetic Resonance ImagingMicroscopy, Electron, TransmissionPositron-Emission TomographyContrast Mediadumbbell structureshybridnanotrimerspositron emission tomographyT1/T2-weighted magnetic resonance imaging

Identifiers

PMID25283972
PMCPMC4334264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.