Evidence map›Paper›PMID 25283971›Full record

ReviewTrends in biotechnology2014

Emerging microengineered tools for functional analysis and phenotyping of blood cells.

Xiang Li, Weiqiang Chen, Zida Li, Ling Li, Hongchen Gu, Jianping Fu

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A Miniaturized Hemoretractometer for Blood Clot Retraction Testing.Small (Weinheim an der Bergstrasse, Germany) · 2016
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xiang LiIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Weiqiang ChenIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Zida LiIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Ling LiDepartment of Precision Instruments, Tsinghua University, Beijing 100084, China.
Hongchen GuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Jianping FuIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: jpfu@umich.edu.
University of Michigan–Ann Arbor · USShanghai Jiao Tong University · CNTsinghua University · CN

Funding

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
Microfluidic Functional Immunophenotyping of Pediatric Patients Following CardiopR01HL119542 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORNELL, TIMOTHY T, FU, JIANPING · 2014 to 2017
$2.7M
NCRR NIH HHS UL1 RR024986NCRR NIH HHS UL1RR024986NHLBI NIH HHS 1R01HL119542NHLBI NIH HHS R01 HL119542
6 · The paper itself

Abstract

The available techniques for assessing blood cell functions are limited considering the various types of blood cell and their diverse functions. In the past decade, rapid advances in microengineering have enabled an array of blood cell functional measurements that are difficult or impossible to achieve using conventional bulk platforms. Such miniaturized blood cell assay platforms also provide the attractive capabilities of reducing chemical consumption, cost, and assay time, as well as exciting opportunities for device integration, automation, and assay standardization. This review summarizes these contemporary microengineered tools and discusses their promising potential for constructing accurate in vitro models and rapid clinical diagnosis using minimal amounts of whole-blood samples.

Indexed as

Blood CellsCytological TechniquesDiagnostic Tests, RoutineHumansMicrofluidic Analytical Techniquesblood cellfunctional analysismicroengineeringmicrofluidicsphenotyping

Identifiers

PMID25283971
PMCPMC4252757
OpenAlexW2085966684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.