ArticleScientific reports2014
A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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Who cites it
69 citing papers in PubMed, 130 citations in OpenAlex.
- Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026Article
- Polymer-based ultrawideband transducers for high resolution hemispherical optoacoustic tomography.Light, science & applications · 2026Article
- Racial Variations in Retinal Oxygen Metabolic Biomarkers in Diabetic Retinopathy: A Pilot Study.Journal of ophthalmology · 2026Article
- Retinal oximetry: new insights into ocular and systemic diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Multimodal photoacoustic microscopy and optical coherence tomography ocular biomarker imaging in Alzheimer's disease in mice.Biomedical optics express · 2024Article
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management.Stroke (Hoboken, N.J.) · 2024Review
- Functional photoacoustic imaging: from nano- and micro- to macro-scale.Nano convergence · 2023Review
- Ultrasensitive broadband photoacoustic microscopy based on common-path interferometric surface plasmon resonance sensing.Photoacoustics · 2022Article
- Spectroscopic photoacoustic microscopic imaging during single spatial scan using broadband excitation light pulses with wavelength-dependent time delay.Photoacoustics · 2022Article
- In-vivo functional and structural retinal imaging using multiwavelength photoacoustic remote sensing microscopy.Scientific reports · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Broadband surface plasmon resonance sensor for fast spectroscopic photoacoustic microscopy.Photoacoustics · 2021Article
- Optical Coherence Tomography and Glaucoma.Annual review of vision science · 2021Review
- Fiber-based photoacoustic remote sensing microscopy and spectral-domain optical coherence tomography with a dual-function 1050-nm interrogation source.Journal of biomedical optics · 2021Article
- Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography.Scientific reports · 2021Article
- Integrating photoacoustic microscopy with other imaging technologies for multimodal imaging.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Advances in Retinal Oximetry.Translational vision science & technology · 2021Review
- Discovery and clinical translation of novel glaucoma biomarkers.Progress in retinal and eye research · 2021Review
- Retinal safety evaluation of photoacoustic microscopy.Experimental eye research · 2021Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Quantitatively determining physiological parameters at a microscopic level in the retina furthers the understanding of the molecular pathways of blinding diseases, such as diabetic retinopathy and glaucoma. An essential parameter, which has yet to be quantified noninvasively, is the retinal oxygen metabolic rate (rMRO2). Quantifying rMRO2 is challenging because two parameters, the blood flow rate and hemoglobin oxygen saturation (sO2), must be measured together. We combined photoacoustic ophthalmoscopy (PAOM) with spectral domain-optical coherence tomography (SD-OCT) to tackle this challenge, in which PAOM measured the sO2 and SD-OCT mapped the blood flow rate. We tested the integrated system on normal wild-type rats, in which the measured rMRO2 was 297.86 ± 70.23 nl/minute. This quantitative method may shed new light on both fundamental research and clinical care in ophthalmology in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.